Angiogenic signaling pathways and anti-angiogenic therapy for cancer
ZL Liu, HH Chen, LL Zheng, LP Sun… - Signal transduction and …, 2023 - nature.com
Angiogenesis, the formation of new blood vessels, is a complex and dynamic process
regulated by various pro-and anti-angiogenic molecules, which plays a crucial role in tumor …
regulated by various pro-and anti-angiogenic molecules, which plays a crucial role in tumor …
[HTML][HTML] Broad targeting of angiogenesis for cancer prevention and therapy
Deregulation of angiogenesis–the growth of new blood vessels from an existing vasculature–
is a main driving force in many severe human diseases including cancer. As such, tumor …
is a main driving force in many severe human diseases including cancer. As such, tumor …
Tumor angiogenesis revisited: regulators and clinical implications
Abstract Since Judah Folkman hypothesized in 1971 that angiogenesis is required for solid
tumor growth, numerous studies have been conducted to unravel the angiogenesis process …
tumor growth, numerous studies have been conducted to unravel the angiogenesis process …
Tumor neovascularization and developments in therapeutics
Y Katayama, J Uchino, Y Chihara, N Tamiya, Y Kaneko… - Cancers, 2019 - mdpi.com
Tumors undergo fast neovascularization to support the rapid proliferation of cancer cells.
Vasculature in tumors, unlike that in wound healing, is immature and affects the tumor …
Vasculature in tumors, unlike that in wound healing, is immature and affects the tumor …
Evading tumor evasion: current concepts and perspectives of anti-angiogenic cancer therapy
A Abdollahi, J Folkman - Drug Resistance Updates, 2010 - Elsevier
Within three decades, anti-angiogenic therapy has rapidly evolved into an integral
component of current standard anti-cancer treatment. Anti-angiogenic therapy has fulfilled a …
component of current standard anti-cancer treatment. Anti-angiogenic therapy has fulfilled a …
The role of angiogenesis in cancer treatment
M Rajabi, SA Mousa - Biomedicines, 2017 - mdpi.com
A number of anti-angiogenesis drugs have been FDA-approved and are being used in
cancer treatment, and a number of other agents are in different stages of clinical …
cancer treatment, and a number of other agents are in different stages of clinical …
Exploring novel methods for modulating tumor blood vessels in cancer treatment
PP Wong, N Bodrug, KM Hodivala-Dilke - Current biology, 2016 - cell.com
Several studies have explored the potential of targeting tumor angiogenesis in cancer
treatment. Anti-angiogenesis monotherapy, which reduces blood vessel numbers, may still …
treatment. Anti-angiogenesis monotherapy, which reduces blood vessel numbers, may still …
Antiangiogenic therapies: going beyond their limits
L Moserle, G Jiménez-Valerio, O Casanovas - Cancer discovery, 2014 - AACR
Tumor growth requires induction of an angiogenic program, and targeting of this program
with antiangiogenic drugs shows an impact on tumor progression. However, although they …
with antiangiogenic drugs shows an impact on tumor progression. However, although they …
Angiogenesis: managing the culprits behind tumorigenesis and metastasis
Deregulated angiogenesis has been identified as a key contributor in a number of
pathological conditions including cancer. It is a complex process, which involves highly …
pathological conditions including cancer. It is a complex process, which involves highly …
Angiogenesis modulation in cancer research: novel clinical approaches
M Cristofanilli, C Charnsangavej… - Nature reviews Drug …, 2002 - nature.com
Angiogenesis—the formation of new blood vessels—is essential for tumour progression and
metastasis. Consequently, the modulation of tumour angiogenesis using novel agents has …
metastasis. Consequently, the modulation of tumour angiogenesis using novel agents has …