Coined in the late eighties, the term “angiogenic switch” refers to a time-restricted event
during tumor progression where the balance between pro-and anti-angiogenic factors tilts …

Formation of new blood vessels (angiogenesis) has been demonstrated to be a basic
prerequisite for sustainable growth and proliferation of tumor. Several growth factors …

Background Angiogenesis is a key and early step in tumorigenesis, and is known as a
hallmark of solid tumors and a key promoter of tumor recurrence. Unlike normal tissue …

Mutations of oncogenes and tumor suppressor genes often lead to transformation of a
normal cell to become a malignant cell. However, most malignant cells cannot grow to a …

Tumors have been recently recognized as aberrant organs composed of a complex mixture
of highly interactive cells that in addition to the cancer cell include stroma (fibroblasts …

Tumor angiogenesis is essential for the growth of primary and metastatic tumors. This
process requires the coordinated activities of multiple factors and cell types. For tumors to …

The induction of neoangiogenesis is a critical step already present at the early stages of
tumor development and dissemination. The progressive identification of molecules playing a …

New growth in the vascular network is important since the proliferation, as well as metastatic
spread, of cancer cells depends on an adequate supply of oxygen and nutrients and the …

Angiogenesis has always been the topic of major scientific interest in the field of malignant
tumors. Nowadays, targeting angiogenesis has achieved success in various carcinomas by …

Angiogenesis is a critical step in the progression of almost all human malignancies and
some other life-threatening diseases. Anti-angiogenic therapy is a novel and effective …