Inflammatory response to cardiopulmonary bypass: mechanisms involved and possible therapeutic strategies

S Wan, JL LeClerc, JL Vincent - Chest, 1997 - Elsevier
Background Recent study of the inflammatory reactions occurring during and after
cardiopulmonary bypass (CPB) has improved our understanding of the involvement of the …

Cardiopulmonary bypass induced inflammation: pathophysiology and treatment. An update

D Paparella, TM Yau, E Young - European Journal of Cardio …, 2002 - academic.oup.com
Cardiac surgery with cardiopulmonary bypass (CPB) induces an acute phase reaction that
has been implicated in the pathogenesis of several postoperative complications. Recent …

Inflammatory response to cardiac surgery: cardiopulmonary bypass versus non-cardiopulmonary bypass surgery

J Larmann, G Theilmeier - Best practice & research Clinical …, 2004 - Elsevier
Cardiac surgery has been routinely performed using cardiopulmonary bypass (CPB) ever
since its clinical introduction during the 1950s. CPB is, however, associated with an intense …

Magnitude of the inflammatory response to cardiopulmonary bypass and its relation to adverse clinical outcomes

JH Holmes Iv, NC Connolly, DL Paull, ME Hill… - Inflammation …, 2002 - Springer
Introduction: Cardiopulmonary bypass (CPB) induces an inflammatory response believed to
contribute to postoperative morbidity. We hypothesized that the magnitude of the …

The inflammatory response to cardiopulmonary bypass: a therapeutic overview

FD Rubens, T Mesana - Perfusion, 2004 - journals.sagepub.com
The demographic of cardiac surgery patients continues to evolve to include older, sicker
candidates, all the while maintaining an expectation of excellent outcomes. These latter …

Impact of off‐pump coronary artery bypass surgery on systemic inflammation: current best available evidence

SG Raja, GA Berg - Journal of cardiac surgery, 2007 - Wiley Online Library
The systemic inflammatory response after coronary artery bypass grafting using
cardiopulmonary bypass (CPB) contributes substantially to postoperative organ dysfunction …

Cardiopulmonary bypass-induced inflammation: is it important?

GE Hill - Journal of cardiothoracic and vascular anesthesia, 1998 - europepmc.org
The systemic endotoxemia that occurs with the institution of cardiopulmonary bypass (CPB)
is a potent stimulus for the release of proinflammatory cytokines, including tumor necrosis …

Inflammatory response to cardiopulmonary bypass

J Butler, GM Rocker, S Westaby - The Annals of thoracic surgery, 1993 - Elsevier
Cardiac operations with cardiopulmonary bypass cause a systemic inflammatory response,
which can lead to organ injury and postoperative morbidity. Causative factors include …

The influence of cardiopulmonary bypass on cytokines and cell-cell communication

GE Hill, CW Whitten, DF Landers - Journal of cardiothoracic and vascular …, 1997 - Elsevier
Cardiopulmonary bypass (CPB) is characterized by systemic endotoxemia immediately after
its onset as well as the systemic release of proinflammatory cytokines, including tumor …

Inflammatory response to cardiopulmonary bypass

JH Levy, KA Tanaka - The Annals of thoracic surgery, 2003 - Elsevier
Inflammation in cardiac surgical patients is produced by complex humoral and cellular
interactions with numerous pathways including activation, generation, or expression of …