The effect of oral treatment with caffeine, in doses that are known to produce marked
adaptive effects, was investigated on A1 and A2A receptors in the mouse brain. Caffeine …

The effect of long-term oral treatment with caffeine on A 1 and A 2 receptors in the rat brain
was studied. Caffeine was added to the drinking water and the animals were sacrificed after …

Chronic administration of caffeine (75 mg/kg/day) to rats for 12 days increased [3 H] R-PIA
binding in the cerebral cortex and cerebellum and [3 H] NECA binding to high affinity …

In order to assess for the respective involvement of adenosine A1 and A2A receptors (A2A‐
R) in the consequences of short‐and long‐term caffeine exposure on gene expression, the …

Caffeine is believed to exert its stimulant effects by blocking A2A and A1 adenosine
receptors (A2AR and A1R). Although a genetic knockout of A2AR eliminates effects of …

Caffeine consumption causes significant physiologic effects due to its antagonism of
adenosine receptors. The A1 adenosine receptor is coupled in an inhibitory manner to …

The widespread use of caffeine-containing beverages has focused research on the
mechanisms underlying the central effects of caffeine. 1–3 While the effects of moderate …

Caffeine is a methylxanthine, commonly used in the premature neonate to treat apnea of
prematurity. It is efficacious and appears to have few short-term side effects. An animal …

The effects of chronic caffeine on the A1 adenosine receptor-adenylate cyclase system of rat
cerebral cortical membranes were studied. Caffeine treatment significantly increased the …

Changes in brain a1 and A2A receptors and in the corresponding mRNA were studied using
quantitative receptor autoradiography and in situ hybridisation.[3H]-DPCPX was used as an …