Precision oncology beyond targeted therapy: combining omics data with machine learning matches the majority of cancer cells to effective therapeutics

MQ Ding, L Chen, GF Cooper, JD Young, X Lu - Molecular cancer research, 2018 - AACR
Precision oncology involves identifying drugs that will effectively treat a tumor and then
prescribing an optimal clinical treatment regimen. However, most first-line chemotherapy …

Artificial intelligence for precision oncology: beyond patient stratification

F Azuaje - NPJ precision oncology, 2019 - nature.com
The data-driven identification of disease states and treatment options is a crucial challenge
for precision oncology. Artificial intelligence (AI) offers unique opportunities for enhancing …

Functional precision cancer medicine—moving beyond pure genomics

A Letai - Nature medicine, 2017 - nature.com
The essential job of precision medicine is to match the right drugs to the right patients. In
cancer, precision medicine has been nearly synonymous with genomics. However, sobering …

Precision oncology based on omics data: the NCT Heidelberg experience

P Horak, B Klink, C Heining, S Gröschel… - … journal of cancer, 2017 - Wiley Online Library
Precision oncology implies the ability to predict which patients will likely respond to specific
cancer therapies based on increasingly accurate, high‐resolution molecular diagnostics as …

Recent advances in precision oncology research

AM Bode, Z Dong - NPJ precision oncology, 2018 - nature.com
Precision oncology has evolved into focusing on matching the most accurate and effective
treatments based not only on the genetic profile of the patient and his/her cancer, but also on …

The coming decade in precision oncology: six riddles

A Wahida, L Buschhorn, S Fröhling, PJ Jost… - Nature Reviews …, 2023 - nature.com
High-throughput methods to investigate tumour omic landscapes have quickly catapulted
cancer specialists into the precision oncology era. The singular lesson of precision oncology …

Drug sensitivity prediction from cell line-based pharmacogenomics data: guidelines for developing machine learning models

H Sharifi-Noghabi… - Briefings in …, 2021 - academic.oup.com
The goal of precision oncology is to tailor treatment for patients individually using the
genomic profile of their tumors. Pharmacogenomics datasets such as cancer cell lines are …

Drug ranking using machine learning systematically predicts the efficacy of anti-cancer drugs

H Gerdes, P Casado, A Dokal, M Hijazi… - Nature …, 2021 - nature.com
Artificial intelligence and machine learning (ML) promise to transform cancer therapies by
accurately predicting the most appropriate therapies to treat individual patients. Here, we …

A Transcriptome-Based Precision Oncology Platform for Patient–Therapy Alignment in a Diverse Set of Treatment-Resistant Malignancies

PS Mundi, FS Dela Cruz, A Grunn, D Diolaiti… - Cancer discovery, 2023 - AACR
Predicting in vivo response to antineoplastics remains an elusive challenge. We performed
a first-of-kind evaluation of two transcriptome-based precision cancer medicine …

[HTML][HTML] Precision medicine in the era of multi-omics: can the data tsunami guide rational treatment decision?

M Aldea, L Friboulet, S Apcher, F Jaulin, F Mosele… - ESMO open, 2023 - Elsevier
Highlights•Actionable alterations should be prioritized by using validated rankings for
treatment tailoring.•High-throughput genomics could refine drivers and find new targets, mini …