Precision oncology beyond targeted therapy: combining omics data with machine learning matches the majority of cancer cells to effective therapeutics
Precision oncology involves identifying drugs that will effectively treat a tumor and then
prescribing an optimal clinical treatment regimen. However, most first-line chemotherapy …
prescribing an optimal clinical treatment regimen. However, most first-line chemotherapy …
Artificial intelligence for precision oncology: beyond patient stratification
F Azuaje - NPJ precision oncology, 2019 - nature.com
The data-driven identification of disease states and treatment options is a crucial challenge
for precision oncology. Artificial intelligence (AI) offers unique opportunities for enhancing …
for precision oncology. Artificial intelligence (AI) offers unique opportunities for enhancing …
Functional precision cancer medicine—moving beyond pure genomics
A Letai - Nature medicine, 2017 - nature.com
The essential job of precision medicine is to match the right drugs to the right patients. In
cancer, precision medicine has been nearly synonymous with genomics. However, sobering …
cancer, precision medicine has been nearly synonymous with genomics. However, sobering …
Precision oncology based on omics data: the NCT Heidelberg experience
P Horak, B Klink, C Heining, S Gröschel… - … journal of cancer, 2017 - Wiley Online Library
Precision oncology implies the ability to predict which patients will likely respond to specific
cancer therapies based on increasingly accurate, high‐resolution molecular diagnostics as …
cancer therapies based on increasingly accurate, high‐resolution molecular diagnostics as …
Recent advances in precision oncology research
AM Bode, Z Dong - NPJ precision oncology, 2018 - nature.com
Precision oncology has evolved into focusing on matching the most accurate and effective
treatments based not only on the genetic profile of the patient and his/her cancer, but also on …
treatments based not only on the genetic profile of the patient and his/her cancer, but also on …
The coming decade in precision oncology: six riddles
High-throughput methods to investigate tumour omic landscapes have quickly catapulted
cancer specialists into the precision oncology era. The singular lesson of precision oncology …
cancer specialists into the precision oncology era. The singular lesson of precision oncology …
Drug sensitivity prediction from cell line-based pharmacogenomics data: guidelines for developing machine learning models
H Sharifi-Noghabi… - Briefings in …, 2021 - academic.oup.com
The goal of precision oncology is to tailor treatment for patients individually using the
genomic profile of their tumors. Pharmacogenomics datasets such as cancer cell lines are …
genomic profile of their tumors. Pharmacogenomics datasets such as cancer cell lines are …
Drug ranking using machine learning systematically predicts the efficacy of anti-cancer drugs
H Gerdes, P Casado, A Dokal, M Hijazi… - Nature …, 2021 - nature.com
Artificial intelligence and machine learning (ML) promise to transform cancer therapies by
accurately predicting the most appropriate therapies to treat individual patients. Here, we …
accurately predicting the most appropriate therapies to treat individual patients. Here, we …
A Transcriptome-Based Precision Oncology Platform for Patient–Therapy Alignment in a Diverse Set of Treatment-Resistant Malignancies
PS Mundi, FS Dela Cruz, A Grunn, D Diolaiti… - Cancer discovery, 2023 - AACR
Predicting in vivo response to antineoplastics remains an elusive challenge. We performed
a first-of-kind evaluation of two transcriptome-based precision cancer medicine …
a first-of-kind evaluation of two transcriptome-based precision cancer medicine …
[HTML][HTML] Precision medicine in the era of multi-omics: can the data tsunami guide rational treatment decision?
Highlights•Actionable alterations should be prioritized by using validated rankings for
treatment tailoring.•High-throughput genomics could refine drivers and find new targets, mini …
treatment tailoring.•High-throughput genomics could refine drivers and find new targets, mini …
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