The accumulated evidence has pointed to a key role of telomerase in carcinogenesis. As a
RNA-dependent DNA polymerase, telomerase synthesizes telomeric DNA at the end of …

Malignant transformation from mortal, normal cells to immortal, cancer cells is generally
associated with activation of telomerase and subsequent telomere maintenance. A major …

Telomeres are specialized structures at the ends of eukaryotic chromosomes and are crucial
for genome stability, cell growth control and carcinogenesis. Normally, they protect …

The telomerase holoenzyme, which has a highly conserved role in maintaining telomere
length, has long been regarded as a high-profile target in cancer therapy due to the high …

Telomerase activity is dependent on the expression of 2 main core component genes,
hTERT, which encodes the catalytic component and hTR (also called TERC), which …

Telomere attrition limits the replicative potential of most somatic cells. In contrast, tumor cells
acquire immortality by continuous telomere maintenance which is predominantly due to the …

The maintenance of specialized nucleoprotein structures termed telomeres is essential for
chromosome stability. Without new synthesis of telomeres at chromosome ends the …

The telomerase ribonucleoprotein complex has a pivotal role in regulating the proliferation
and senescence of normal somatic cells as well as cancer cells. This complex is comprised …

Telomere repeats at chromosomal ends, critical to genome integrity, are maintained through
an elaborate network of proteins and pathways. Shelterin complex proteins shield telomeres …

Telomerase activity is essential for human cancer cells in order to maintain telomeres and
provide unlimited proliferation potential and cellular immortality. However, additional non …