Amyloid Aβ25-35 aggregates say 'NO'to long-term potentiation in the hippocampus through activation of stress-induced phosphatase 1 and mitochondrial Na+/Ca2+ …
AV Maltsev, AB Nikiforova, NV Bal… - International Journal of …, 2022 - mdpi.com
The search for strategies for strengthening the synaptic efficiency in Aβ25-35-treated slices
is a challenge for the compensation of amyloidosis-related pathologies. Here, we used the …
is a challenge for the compensation of amyloidosis-related pathologies. Here, we used the …
Influence of Nitric Oxide–Cyclic GMP and Oxidative STRESS on Amyloid-β Peptide Induced Decrease of Na, K-ATPase Activity in Rat Hippocampal Slices
EM Kawamoto, MM Cararo-Lopes, PF Kinoshita… - The Journal of …, 2021 - Springer
Amyloid-β peptide (Aβ) has been shown to cause synaptic dysfunction and can render
neurons vulnerable to excitotoxicity and oxidative stress. Na, K-ATPase plays an important …
neurons vulnerable to excitotoxicity and oxidative stress. Na, K-ATPase plays an important …
Exploring the consequences of calcium dysregulation induced by Alzheimer's disease onset: Focus on synaptic dysfunctions
Synaptic dysfunction is one of the earliest hallmarks of Alzheimer's disease (AD) and
accumulation of oligomers of amyloid beta (Abeta) peptides is one initiating events that …
accumulation of oligomers of amyloid beta (Abeta) peptides is one initiating events that …
Rosiglitazone prevents amyloid-β oligomer-induced impairment of synapse formation and plasticity via increasing dendrite and spine mitochondrial number
Rosiglitazone has been known to attenuate neurodegeneration in Alzheimer's disease (AD),
but the underlying mechanisms remain to be fully elucidated. In this study, living-cell image …
but the underlying mechanisms remain to be fully elucidated. In this study, living-cell image …
Aβ induces acute depression of excitatory glutamatergic synaptic transmission through distinct phosphatase-dependent mechanisms in rat CA1 pyramidal neurons
W Yao, HJ Zou, D Sun, SQ Ren - Brain research, 2013 - Elsevier
Beta-amyloid peptide (Aβ) has a causal role in the pathophysiology of Alzheimer's disease
(AD). Recent studies indicate that Aβ can disrupt excitatory glutamatergic synaptic function …
(AD). Recent studies indicate that Aβ can disrupt excitatory glutamatergic synaptic function …
Xestospongin C, a Reversible IP 3 Receptor Antagonist, Alleviates the Cognitive and Pathological Impairments in APP/PS1 Mice of Alzheimer's Disease
ZJ Wang, F Zhao, CF Wang, XM Zhang… - Journal of …, 2019 - content.iospress.com
Exaggerated Ca 2+ signaling might be one of primary causes of neural dysfunction in
Alzheimer's disease (AD). And the intracellular Ca 2+ overload has been closely associated …
Alzheimer's disease (AD). And the intracellular Ca 2+ overload has been closely associated …
The Ca2+ channel inhibitor 2‐APB reverses β‐amyloid‐induced LTP deficit in hippocampus by blocking BAX and caspase‐3 hyperactivation
WY Hu, ZY He, LJ Yang, M Zhang… - British journal of …, 2015 - Wiley Online Library
Background and Purpose At the early stage of Alzheimer's disease (AD), the accumulation
of β‐amyloid (A β) oligomers disturbs intracellular Ca2+ homeostasis and disrupts synaptic …
of β‐amyloid (A β) oligomers disturbs intracellular Ca2+ homeostasis and disrupts synaptic …
Physiological concentrations of amyloid beta regulate recycling of synaptic vesicles via alpha7 acetylcholine receptor and CDK5/calcineurin signaling
V Lazarevic, S Fieńko, M Andres-Alonso… - Frontiers in molecular …, 2017 - frontiersin.org
Despite the central role of amyloid β (Aβ) peptide in the etiopathogenesis of Alzheimer's
disease (AD), its physiological function in healthy brain is still debated. It is well established …
disease (AD), its physiological function in healthy brain is still debated. It is well established …
Neuromodulatory action of picomolar extracellular Aβ42 oligomers on presynaptic and postsynaptic mechanisms underlying synaptic function and memory
W Gulisano, M Melone, C Ripoli… - Journal of …, 2019 - Soc Neuroscience
Failure of anti-amyloid-β peptide (Aβ) therapies against Alzheimer's disease (AD), a
neurodegenerative disorder characterized by high amounts of the peptide in the brain …
neurodegenerative disorder characterized by high amounts of the peptide in the brain …
Oligomer β-amyloid induces hyperactivation of Ras to impede NMDA receptor-dependent long-term potentiation in hippocampal CA1 of mice
Y Wang, Z Shi, Y Zhang, J Yan, W Yu… - Frontiers in …, 2020 - frontiersin.org
The activity of Ras, a small GTPase protein, is increased in brains with Alzheimer's disease.
The objective of this study was to determine the influence of oligomeric Aβ1-42 on the …
The objective of this study was to determine the influence of oligomeric Aβ1-42 on the …