Acetylcholine (ACh) signaling shapes neuronal circuit development and underlies specific
aspects of cognitive functions and behaviors, including attention, learning, memory and …

Huntington's disease (HD) is classically characterized as a movement disorder, however
cognitive impairments precede the motor symptoms by∼ 15 y. Based on proteomic and …

Sleep regulation involves interdependent signaling among specialized neurons in
distributed brain regions. Although acetylcholine promotes wakefulness and rapid eye …

The central cholinergic system and the amygdala are important for motivation and
mnemonic processes. Different cholinergic populations innervate the amygdala, but it is …

Cholinergic projections to the cortex and hippocampus mediate fundamental cognitive
processes. The capacity of the high-affinity choline uptake transporter (CHT) to import …

The parasubthalamic nucleus (PSTN) is considered to be involved in motivation, feeding
and hunting, all of which are highly depending on wakefulness. However, the roles and …

Publisher Summary This chapter focuses on the structural features of vesicular acetylcholine
transporter (VAChT) deduced from its primary sequence, which give insight into its …

Rationale Mice lacking the dopamine transporter (DAT) display major behavioral alterations
that include hyperactivity, perseverative locomotor patterns, and reduced prepulse inhibition …

ACh is a signaling molecule in the mammalian CNS, with well-documented influence over
cognition and behavior. However, the nature of cholinergic signaling in the brain remains …

The sequence encoding the vesicular acetylcholine transporter (VAChT) has recently been
localized within the first intron of the choline acetyltransferase (ChAT) gene in various …