Cholinergic double duty: cue detection and attentional control
Highlights•Cholinergic signaling in cortex occurs on multiple time scales.•Fast cholinergic
signaling mediates bottom-up, or cue-driven attention.•Slower (neuromodulatory) …
signaling mediates bottom-up, or cue-driven attention.•Slower (neuromodulatory) …
Coregulation of two embedded gene products, choline acetyltransferase and the vesicular acetylcholine transporter
S Berrard, H Varoqui, R Cervini, M Israël… - Journal of …, 1995 - Wiley Online Library
The gene encoding the vesicular acetylcholine transporter (VAChT) has recently been
localized within the first intron of the gene encoding choline acetyltransferase (ChAT) and is …
localized within the first intron of the gene encoding choline acetyltransferase (ChAT) and is …
Coordinate expression of vesicular acetylcholine transporter and choline acetyltransferase in sympathetic superior cervical neurones
H Misawa, R Takahashi, T Deguchi - Neuroreport, 1995 - journals.lww.com
The neurotransmitter acetylcholine is synthesized by choline acetyltransferase (ChAT) and
transported into synaptic vesicles by the vesicular acetylcholine transporter (VAChT) …
transported into synaptic vesicles by the vesicular acetylcholine transporter (VAChT) …
Cortical cholinergic signaling controls the detection of cues
The cortical cholinergic input system has been described as a neuromodulator system that
influences broadly defined behavioral and brain states. The discovery of phasic, trial-based …
influences broadly defined behavioral and brain states. The discovery of phasic, trial-based …
Serotonin-mediated central fatigue underlies increased endurance capacity in mice from lines selectively bred for high voluntary wheel running
GC Claghorn, IAT Fonseca, Z Thompson, C Barber… - Physiology & …, 2016 - Elsevier
Abstract Serotonin (5-hydroxytryptamine; 5-HT) is implicated in central fatigue, and 5-HT 1A
pharmaceuticals are known to influence locomotor endurance in both rodents and humans …
pharmaceuticals are known to influence locomotor endurance in both rodents and humans …
The benefits of cholinergic enhancement during perceptual learning are long-lasting
The neurotransmitter acetylcholine (ACh) regulates many aspects of cognition, including
attention and memory. Previous research in animal models has shown that plasticity in …
attention and memory. Previous research in animal models has shown that plasticity in …
A review of the cholinergic system and therapeutic approaches to treat brain disorders
D Bertrand, TL Wallace - Behavioral Pharmacology of the Cholinergic …, 2020 - Springer
Since its identification over a hundred years ago, the neurotransmitter acetylcholine (ACh)
has proven to play an essential role in supporting many diverse functions. Some well …
has proven to play an essential role in supporting many diverse functions. Some well …
Molecular mechanisms of REM sleep
Rapid-eye movement (REM) sleep is a paradoxical sleep state characterized by brain
activity similar to wakefulness, rapid-eye-movement, and lack of muscle tone. REM sleep is …
activity similar to wakefulness, rapid-eye-movement, and lack of muscle tone. REM sleep is …
Cell type–specific channelrhodopsin-2 transgenic mice for optogenetic dissection of neural circuitry function
S Zhao, JT Ting, HE Atallah, L Qiu, J Tan, B Gloss… - Nature …, 2011 - nature.com
Optogenetic methods have emerged as powerful tools for dissecting neural circuit
connectivity, function and dysfunction. We used a bacterial artificial chromosome (BAC) …
connectivity, function and dysfunction. We used a bacterial artificial chromosome (BAC) …
Muscarinic acetylcholine receptors activate the acetylcholinesterase gene promoter
RM Nitsch, S Rossner, C Albrecht, M Mayhaus… - Journal of Physiology …, 1998 - Elsevier
The acetylcholinesterase (AChE) gene promoter contains several overlapping binding sites
for Spl and Egr-1 transcription factors. Cotransfection experiments and promoter assays …
for Spl and Egr-1 transcription factors. Cotransfection experiments and promoter assays …