Advances in the technology of human cell and tissue culture and the increasing availability
of human tissue for laboratory studies have led to the increased use of in vitro human tissue …

In vitro models are being used increasingly during all phases of the drug development
process in concert with the more traditional in vivo toxicological and pharmacokinetic …

The increasing use of tissue dosimetry estimated using pharmacokinetic models in chemical
risk assessments in various jurisdictions necessitates the development of internationally …

The cancer model contains extensive biological detail, but is not fully validated. It is
extremely useful for organizing what is known about malignant transformation, for linking …

The adverse biological effects of toxic substances are dependent upon the exposure
concentration and the duration of exposure. Pharmacokinetic models can quantitatively …

The dose to target tissues is the net result of absorption, distribution, metabolism, and
excretion (ADME) of substances in biota. Knowledge of target tissue dose or internal …

The introduction of in vitro methodologies in the toxicological risk assessment process
requires a number of prerequisites regarding both the toxicodynamics and the biokinetics of …

An important issue in toxicology is the suitability of the data obtained with experimental
animals for human risk assessment. Because it is not possible to use humans in long-term …

The field of toxicology is currently undergoing a global paradigm shift to use of in vitro
approaches for assessing the risks of chemicals and drugs in a more mechanistic and high …

In Vitro Methods in Pharmaceutical Research provides a comprehensive guide to laboratory
techniques for evaluating in vitro organ toxicity using cellular models. Step-by-step practical …