Background: Anemia affects~ 25% of the world population and is frequently caused by iron
deficiency as a consequence of malnutrition or inflammation. Only in rare cases anemia is …

Abstract Transferrin receptor 2 (TFR2) contributes to hepcidin regulation in the liver and
associates with erythropoietin receptor in erythroid cells. Nevertheless, TFR2 mutations …

Iron metabolism and erythropoiesis are inherently interlinked physiological processes.
Regulation of iron metabolism is mediated by the iron‐regulatory hormone hepcidin …

Erythroid cells consume the vast majority (70-80%) of body iron for synthesis of heme, the
oxygen-binding cofactor of hemoglobin (Hb). Under physiological conditions, plasma iron is …

Abstract Transferrin receptor 2 (TFR2) is a transmembrane glycoprotein expressed in the
liver and in the erythroid compartment, mutated in a form of hereditary hemochromatosis …

Background Hepcidin plays a key role in body iron metabolism by preventing the release of
iron from macrophages and intestinal cells. Defective hepcidin synthesis causes iron …

The notion that humans have two types of transferrin receptor is rather recent. The classical
transferrin receptor (TFR1) is a key molecule, essential for iron uptake through its …

Transferrin receptor 2 (TFR2), a protein homologous to the cell iron importer TFR1, is
expressed in the liver and erythroid cells and is reported to bind diferric transferrin, although …

Transferrin receptor 2 (TFR2) is a transmembrane protein expressed mainly in hepatocytes
and in developing erythroid cells and is an important focal point in systemic iron regulation …

Haemochromatosis (HC) refers to a group of inherited disorders of iron metabolism
characterized by progressive iron accumulation in parenchymal cells. If not recognized and …