We have investigated the contributions of three polymorphic markers in the SRD5A2 gene to
prostate cancer in a group of Italian patients. We have genotyped cases and controls for a …

OBJECTIVES:: To compare men with prostate disease with those from the general
population regarding polymorphisms in the androgen receptor gene and in the 5α-reductase …

Materials and Methods We studied a group of 107 patients with prostate cancer, as well as a
control group of 102 healthy males that were matched with the patients by age and ethnicity …

This Prostate Cancer Center initiation grant has been designed to identify genetic and
molecular markers of prostate cancer progression within and between racial ethnic groups …

Controversy exists over the significance of associations between the SRD5A2 (5α‐
reductase type 2) polymorphisms, A49T and V89L, and risk of prostate cancer. These …

The pathogenetic mechanism of prostate cancer (PCa) has not been understood completely,
and gene polymorphisms have been demonstrated to play a critical role in the course. It has …

Prostate cancer (PRCa) is one of the most common causes of cancer death in men and
determinants of PRCa risk remain largely unidentified. This study design to assess the …

Numerous investigations have examined the associations between steroid 5-alpha-
reductase type 2 (SRD5A2) V89L and A49T polymorphisms and prostate cancer risk; …

BACKGROUND: The relationship between inherited germ-line variations in the 5α-
reductase pathways of androgen biosynthesis and the risk of biochemical recurrence (BCR) …

PURPOSE: The SRD5A2 gene codes the steroid 5-reductase type II, a critical mediator of
androgen action, and the V89L and A49T polymorphisms of this gene may be associated …