Background: Missense polymorphism in HSD3B1, encoding 3β-hydroxysteroid
dehydrogenase-1, was associated with outcome after abiraterone treatment. Other …

Elevated dihydrotestosterone levels have been suggested to increase the risk of prostate
cancer. The human SRD5A2 gene encodes the type II steroid 5α-reductase, which converts …

The use of 5α‑reductase inhibitors (5α‑RIs) as prostate cancer chemoprevention agents is
controversial. Two large randomized trials, the Prostate Cancer Prevention Trial (PCPT) and …

Finasteride and dutasteride are 5-alpha reductase inhibitors (5-ARIs) which have been
shown to improve symptoms of benign prostatic hyperplasia (BPH) and reduce the risk of …

Prostate cancer (PCa) is the most common male malignancy in the Western world. The
traditional treatments, such as surgery or radiation, are associated with significant adverse …

BACKGROUND Dihydrotestosterone (DHT) is believed to play an important role in prostate
carcinogenesis. Five alpha reductase type II (SRD5A2) and 3 beta‐hydroxysteroid …

METHODS: We conducted a genome-wide SNP association study on 300 advanced
prostate cancer suitable for androgen deprivation and 312 healthy controls matched for age …

The presence of the genetic variants of the steroid 5‑alpha reductase 2 enzyme, which is
encoded by the SRD5A2 gene, has been associated with an increased risk of developing …

Abstract The steroid-5-alpha-reductase, alpha polypeptide 2 (SRD5A2) gene plays a crucial
role in androgen metabolism pathway in human prostate. It encodes SRD5A2 enzyme …

Objective: To determine the association of missense substitution of alanine 49 threonine
(A49T) and valine 89 leucine (V89L) in the steroid-5-alpha-reductase type II (SRD5A2) gene …