The GH/IGF axis plays an important role in the control of pre and postnatal growth. At least
48 monogenic defects have been described affecting the production, secretion, and action of …

Experimental data support a role for GH and IGF-I in the reproductive process in humans,
but the effect of chronic GH excess on gonadal and reproductive function in men has been …

OBJECTIVE The aim of the study was to evaluate the IGF-I generation test (IGF-I gen) as a
possible indirect test of Growth Hormone (GH) secretory status. METHODS Sixty-five GH …

Longitudinal growth in humans follows a unique pattern that is character-ized by rapid fetal
growth, deceleration immediately after birth, a prolonged childhood growth phase, an …

Serum levels of insulin-like growth factor-I (IGF-I) increase with age and pubertal
development. The large variation in circulating IGF-I levels in adolescence makes it difficult …

The GH/IGF1 system, like other endocrine systems, is dynamic and its activity changes with
age and sexual maturation, and is influenced by body composition and other factors. A …

Despite the dramatic photographs of giants and dwarfs commonly found in textbooks of
endocrinology or as entries in The Guinness Book of World Records, human growth is, in …

The process of growth is complex and is influenced by various factors that act centrally and
peripherally. The genetic control of human growth is becoming increasingly clear. Many …

In patients with acromegaly, there is a linear association between log10 serum GH and IGF-
I. Healthy females secrete three times more GH than males but have broadly similar serum …

The aim of this study was to analyze the possible implication of changes in the GH/IGF-I axis
and in insulin sensitivity for the regulation of adrenal androgen secretion of normal …