Neurons are long-lived cells with a complex architecture, in which synapses may be located
far away from the cell body and are subject to plastic changes, thereby posing special …

The complex morphology of neurons, the specific requirements of synaptic
neurotransmission and the accompanying metabolic demands create a unique challenge for …

Synapses maintain their molecular composition, plasticity and function through the
concerted action of protein synthesis and removal. The complex and polarized neuronal …

Brain synapses pose special challenges on the quality control of their protein machineries
as they are far away from the neuronal soma, display a high potential for plastic adaptation …

Proteome integrity is maintained by a coordinated network of molecular chaperones, by
protein degradation machineries and by their regulators. Numerous human pathologies are …

Protein homeostasis (proteostasis) is crucial to the maintenance of neuronal integrity and
function. As the contact sites between neurons, synapses rely heavily on precisely regulated …

As the sites of communication between neurons, synapses depend upon precisely regulated
protein-protein interactions to support neurotransmitter release and reception. Moreover …

Synaptic function crucially relies on the constant supply and removal of neuronal
membranes. The morphological complexity of neurons poses a significant challenge for …

Highlights•Efficacy of autophagic clearance is critical for neuronal homeostasis and
maintenance.•Restoring autophagy is a promising avenue to delay brain aging.• …

Highlights•In neurons, most autophagosomes form in axon terminals.•In neurons, autophagy
is involved in quality control of synaptic components.•Distinct synaptic proteins interact with …