The mechanism of human T-cell leukemia virus (HTLV)-mediated transformation and
induction of malignancy is unknown; however, several studies have implicated the viral …

A mutational analysis of human T-cell leukemia virus type 2 (HTLV-2) Tax (Tax-2) was
performed to identify regions within Tax-2 important for activation of promoters through the …

Human T-cell leukemia virus type 1 (HTLV-1) and HTLV-2 are retroviruses with similar
biological properties. Whereas HTLV-1 is the causative agent of an aggressive T-cell …

Human T-cell leukemia virus type I (HTLV-I) is an oncogenic retrovirus that was isolated in
1980 from a patient with adult T-cell leukemia. From numerous experiments using infected …

Human T-cell leukemia virus and simian T-cell leukemia virus (STLV) form the primate T-cell
lymphotropic viruses group. Human T-cell leukemia virus type 1 and type 2 (HTLV-1 and …

Human T-cell leukemia virus type 1 (HTLV-1) infects and transforms CD4+ T-lymphocytes
both in vivo and in vitro. Although the Tax protein of HTLV-1 has been strongly implicated as …

Expression of human T-cell leukemia virus type 1 (HTLV-1) is regulated both by the HTLV-1
Tax transactivator and by cellular transcriptional factors binding to the viral long terminal …

Adult T-cell leukemia (ATL) is associated with prior infection with human T-cell leukemia
virus type 1 (HTLV-1). TAX, the major transactivator of HTLV-1, has been implicated in the …

The human T-cell leukemia virus type 1 (HTLV-1) transcriptional trans-activator Tax has
been demonstrated to have transforming activity in multiple cell culture and transgenic …

Human T-cell leukemia virus type 1 (HTLV-1) is the causative agent of two diseases: adult T-
cell leukemia (ATL), a fatal T-lymphoproliferative disorder, and tropical spastic …