Objective We investigated the effects of celecoxib, diclofenac, and ibuprofen on the disease-
specific quality of life, synovial fluid cytokines and signal transduction pathways in …

Objective Despite an extensive body of research on nonsteroidal antiinflammatory drugs
(NSAIDs) in osteoarthritis, the duration of their efficacy and timeline of adverse event (AE) …

Objective To compare the efficacy and safety of topical nonsteroidal anti-inflammatory drugs
(NSAIDs) against placebo and active controls for improving pain and physical function of …

Background. Non‐steroidal anti‐inflammatory drugs (NSAIDs) are widely used to treat
osteoarthritis (OA), though their long‐term efficacy is uncertain. We report a comparison of …

Objective: To compare the effect of celecoxib with that of a classic non-steroidal anti-
inflammatory drug (NSAID) on synovial inflammation and on the synovial expression of …

NSAIDs are widely used to alleviate the symptoms of OA. It remains controversial as to what
effects these agents have on the progression of OA. In vitro studies showed several types of …

Objective To compare the efficacy and tolerability of celecoxib and ibuprofen for the
treatment of knee osteoarthritis symptoms. Method In this 6-week, multicentre, double-blind …

The aim of this study was to identify inflammatory mediators of potential clinical relevance in
synovial fluid (SF) samples of patients with knee osteoarthritis (OA). Therefore, radiographic …

Aim To compare the efficacy, tolerability and safety of celecoxib, naproxen and placebo in
Asian patients with osteoarthritis (OA) of the knee. Method Patients of Asian descent with …

Objective The effect of short‐term and long‐term use of nonsteroidal antiinflammatory drugs
(NSAIDs) on structural change is equivocal. The aim of this study was to estimate the extent …