Boric acid exert anti-cancer effect in poorly differentiated hepatocellular carcinoma cells via inhibition of AKT signaling pathway

E Kahraman, E Göker - Journal of Trace Elements in Medicine and Biology, 2022 - Elsevier
Background The possible anti-cancer properties of boron, a trace element for humans, have
been demonstrated in various experimental and epidemiological studies, although the …

Boric acid suppresses cell proliferation by TNF signaling pathway mediated apoptosis in SW-480 human colon cancer line

M Sevimli, D Bayram, M Özgöçmen, I Armağan… - Journal of Trace …, 2022 - Elsevier
Abstract Background/Aim Colon cancer is one of the most common cancers. Treatment
success and survival rates are not high enough with current approaches. Therefore, there is …

[PDF][PDF] Borax-induced apoptosis in HepG2 cells involves p53, Bcl-2, and Bax

Y Wei, FJ Yuan, WB Zhou, L Wu, L Chen, JJ Wang… - Genet Mol …, 2016 - funpecrp.com.br
Borax, a boron compound and a salt of boric acid, is known to inhibit the growth of tumor
cells. HepG2 cells have been shown to be clearly susceptible to the anti-proliferative effects …

Anti-cancer effect of boron derivatives on small-cell lung cancer

E Cebeci, B Yüksel, F Şahin - Journal of Trace Elements in Medicine and …, 2022 - Elsevier
Background Anti-cancer activity of boron has been reported. Although many boron
derivatives such as boric acid (BA) have been discovered to have anticancer effects, there …

In vitro effects of boric acid on human liver hepatoma cell line (HepG2) at the half-maximal inhibitory concentration

A Tombuloglu, H Copoglu, Y Aydin-Son… - Journal of Trace Elements …, 2020 - Elsevier
Background Boron is a prominent part of the human diet and one of the essential trace
elements for humans. Dietary boron is mostly transformed into boric acid within the body and …

Comparative effects of boric acid and calcium fructoborate on breast cancer cells

R Scorei, R Ciubar, CM Ciofrangeanu, V Mitran… - Biological trace element …, 2008 - Springer
Recent studies suggested that boron has a chemo-preventive role in prostate cancer. In the
present report, we investigated the effects of calcium fructoborate (CF) and boric acid (BA) …

Therapeutic effects of newly synthesized boron compounds (BGM and BGD) on hepatocellular carcinoma

MK Gündüz, M Bolat, G Kaymak, D Berikten… - … Trace Element Research, 2022 - Springer
Boron has an important potential for facilitating biological activity and for use in
pharmaceutical drug design. Boron glycine monoester (BGM) and boron glycine diester …

Boron inhibits the proliferating cell nuclear antigen index, molybdenum containing proteins and ameliorates oxidative stress in hepatocellular carcinoma

H Zafar, S Ali - Archives of biochemistry and biophysics, 2013 - Elsevier
Hepatocellular carcinoma (HCC) is a common malignancy and the main cause of mortality
in patients with chronic liver diseases. This study reports the inhibitory effect of boron on …

[HTML][HTML] Synergistic anti-cancer effect of sodium pentaborate pentahydrate, curcumin and piperine on hepatocellular carcinoma cells

Z Omeroglu Ulu, NS Degirmenci, ZB Bolat, F Sahin - Scientific Reports, 2023 - nature.com
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death in the world.
Poor prognosis of HCC patients is a major issue, thus, better treatment options for patients …

Boric acid as a promising agent in the treatment of ovarian cancer: Molecular mechanisms

U Cabus, M Secme, C Kabukcu, N Cil, Y Dodurga… - Gene, 2021 - Elsevier
Purpose The aim of this study is to determine the therapeutic effects of boric acid cell
proliferation, invasion, migration, colony formation, cell cycle and apoptosis mechanisms in …