Positron emission tomography with [18F]fluorodeoxyglucose to evaluate neutrophil kinetics during acute lung injury

DL Chen, DP Schuster - American Journal of Physiology …, 2004 - journals.physiology.org
We measured neutrophil glucose uptake with positron emission tomographic imaging and
[18F] fluorodeoxyglucose ([18F] FDG-PET) in anesthetized dogs after intravenous oleic acid …

Molecular imaging of lung glucose uptake after endotoxin in mice

Z Zhou, J Kozlowski, AL Goodrich… - … of Physiology-Lung …, 2005 - journals.physiology.org
Positron emission tomographic imaging after administration of the glucose analog fluorine-
18 fluorodeoxyglucose ([18F] FDG) may be useful to study neutrophilic inflammation of the …

Comparison of methods to quantitate 18F-FDG uptake with PET during experimental acute lung injury

DL Chen, MA Mintun, DP Schuster - Journal of Nuclear Medicine, 2004 - Soc Nuclear Med
PET with 18F-FDG may be useful for quantifying neutrophilic activation. We previously
demonstrated that pulmonary neutrophil sequestration could be detected during acute lung …

18F-fluoro-2-deoxyglucose PET informs neutrophil accumulation and activation in lipopolysaccharide-induced acute lung injury

RS Rodrigues, FA Bozza, CJ Hanrahan… - Nuclear medicine and …, 2017 - Elsevier
Introduction Molecular imaging of the earliest events related to the development of acute
lung injury (ALI)/acute respiratory distress syndrome (ARDS) could facilitate therapeutic …

Assessment of Lung Inflammation With 18F-FDG PET During Acute Lung Injury

N de Prost, MR Tucci, MFV Melo - American Journal of …, 2010 - Am Roentgen Ray Soc
OBJECTIVE. The purpose of this review is to describe the current experimental and clinical
data regarding the fundamentals and applications of 18F-FDG PET during acute lung injury …

Dissociation between respiratory burst activity and deoxyglucose uptake in human neutrophil granulocytes: implications for interpretation of 18F-FDG PET images

HA Jones, KA Cadwallader, JF White… - Journal of Nuclear …, 2002 - Soc Nuclear Med
Neutrophil granulocytes play a key role in the pathogenesis of a wide variety of pulmonary
diseases. In many such conditions, the injury observed reflects the activation status rather …

Lungs of patients with acute respiratory distress syndrome show diffuse inflammation in normally aerated regions: a [18F]-fluoro-2-deoxy-D-glucose PET/CT study

G Bellani, C Messa, L Guerra, E Spagnolli… - Critical care …, 2009 - journals.lww.com
Objective: Neutrophilic inflammation plays a key role in the pathogenesis of acute
respiratory distress syndrome (ARDS) and acute lung injury (ALI). Positron emission …

In vivo measurement of neutrophil activity in experimental lung inflammation.

HA Jones, RJ Clark, CG Rhodes… - American journal of …, 1994 - atsjournals.org
Positron emission tomography (PET) was used to quantify 18fluorodeoxyglucose (18FDG)
uptake in rabbits with experimental pneumonitis localized to the right upper lobe. In …

FDG-PET imaging of pulmonary inflammation in healthy volunteers after airway instillation of endotoxin

DL Chen, DB Rosenbluth, MA Mintun… - Journal of Applied …, 2006 - journals.physiology.org
Recent studies indicate that a focal, limited, inflammatory response can be safely elicited
after direct bronchial instillation of small doses of endotoxin into a single lung segment …

Early inflammation mainly affects normally and poorly aerated lung in experimental ventilator-induced lung injury

JB Borges, ELV Costa, F Suarez-Sipmann… - Critical care …, 2014 - journals.lww.com
Objective: The common denominator in most forms of ventilator-induced lung injury is an
intense inflammatory response mediated by neutrophils. PET with [18 F] fluoro-2-deoxy-D …