IL-20 was discovered 10 years ago as a new member of the IL-10 family of cytokines. IL-20
shares the highest amino-acid sequence identity with IL-10, IL-24 and IL-19. IL-20 is …

Interleukin 20 (IL-20) is a pleotropic IL-10 family cytokine that protects epithelial surfaces
from pathogens. However, dysregulated IL-20 signaling is implicated in several human …

Cell-mediated immunity (CMI) plays an essential role in human host defense against
intracellular bacteria. Type-1 cytokines, particularly gamma interferon (IFN-γ), interleukin-12 …

Objective The heterodimeric IL-12 family member cytokines including, IL-12, IL-23, IL-27,
and IL-35 and have multiple roles in regulating innate and adaptive immunity with crucial …

Long-term resistance to many infections depends on the innate ability of the immune system
to coordinate the development of antigen-specific adaptive responses. Deficiencies in these …

Production of cytokines by immune cells in response to stimuli and the binding of cytokines
to specific receptors on target cells is a central feature of the immune response. The IL-12 …

Abstract The interleukin 12 (IL-12) family is unique in having the only heterodimeric
cytokines, including IL-12, IL-23, IL-27 and IL-35. This feature endows these cytokines with a …

Recent discoveries of interleukin (IL)-23, its receptor, and its signal-transduction pathway
add to our understanding of cellular immunity. IL-23 is a heterodimer, comprising IL-12 p40 …

Abstract Interleukin-17A (IL-17A), the hallmark cytokine of the newly defined T helper 17
(TH17) cell subset, has important roles in protecting the host against extracellular …

The functional characterization and subsequent purification of T cell growth factor/interleukin
(IL)-2 in the early 1980s established this secreted protein as a key mediator of immune cell …