Stem cell factor SOX2 confers ferroptosis resistance in lung cancer via upregulation of SLC7A11
X Wang, Y Chen, X Wang, H Tian, Y Wang, J Jin… - Cancer research, 2021 - AACR
Ferroptosis is a lipid peroxidation-dependent cell death caused by metabolic dysfunction.
Ferroptosis-associated enzymes are promising therapeutic targets for cancer treatment …
Ferroptosis-associated enzymes are promising therapeutic targets for cancer treatment …
[HTML][HTML] Amino acid transporter SLC38A5 is a tumor promoter and a novel therapeutic target for pancreatic cancer
T Sniegowski, D Rajasekaran, SR Sennoune… - Scientific Reports, 2023 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) cells have a great demand for nutrients in the
form of sugars, amino acids, and lipids. Particularly, amino acids are critical for cancer …
form of sugars, amino acids, and lipids. Particularly, amino acids are critical for cancer …
Cystine–glutamate antiporter xCT deficiency suppresses tumor growth while preserving antitumor immunity
MD Arensman, XS Yang, DM Leahy… - Proceedings of the …, 2019 - National Acad Sciences
T cell-invigorating cancer immunotherapies have near-curative potential. However, their
clinical benefit is currently limited, as only a fraction of patients respond, suggesting that …
clinical benefit is currently limited, as only a fraction of patients respond, suggesting that …
[HTML][HTML] xCT-driven expression of GPX4 determines sensitivity of breast cancer cells to ferroptosis inducers
Inducers of ferroptosis such as the glutathione depleting agent Erastin and the GPX4
inhibitor Rsl-3 are being actively explored as potential therapeutics in various cancers, but …
inhibitor Rsl-3 are being actively explored as potential therapeutics in various cancers, but …
[HTML][HTML] A potassium-chloride co-transporter promotes tumor progression and castration resistance of prostate cancer through m6A reader YTHDC1
S Yuan, SH He, LY Li, S Xi, H Weng, JH Zhang… - Cell Death & …, 2023 - nature.com
Abstract SLC12A5, a neuron-specific potassium-chloride co-transporter, has been reported
to promote tumor progression, however, the underlying mechanism remains unclear. Here …
to promote tumor progression, however, the underlying mechanism remains unclear. Here …
[HTML][HTML] The glutamate/cystine xCT antiporter antagonizes glutamine metabolism and reduces nutrient flexibility
CS Shin, P Mishra, JD Watrous, V Carelli… - Nature …, 2017 - nature.com
As noted by Warburg, many cancer cells depend on the consumption of glucose. We
performed a genetic screen to identify factors responsible for glucose addiction and …
performed a genetic screen to identify factors responsible for glucose addiction and …
SLC7A11 expression is associated with seizures and predicts poor survival in patients with malignant glioma
SM Robert, SC Buckingham, SL Campbell… - Science translational …, 2015 - science.org
Glioma is the most common malignant primary brain tumor. Its rapid growth is aided by
tumor-mediated glutamate release, creating peritumoral excitotoxic cell death and vacating …
tumor-mediated glutamate release, creating peritumoral excitotoxic cell death and vacating …
[HTML][HTML] TGF-β1-mediated repression of SLC7A11 drives vulnerability to GPX4 inhibition in hepatocellular carcinoma cells
Abstract System xc− contributes to glutathione (GSH) synthesis and protects cells against
ferroptosis by importing cystine and exchanging it with glutamate. Transforming growth …
ferroptosis by importing cystine and exchanging it with glutamate. Transforming growth …
[HTML][HTML] SLC7A11 regulated by NRF2 modulates esophageal squamous cell carcinoma radiosensitivity by inhibiting ferroptosis
L Feng, K Zhao, L Sun, X Yin, J Zhang, C Liu… - Journal of Translational …, 2021 - Springer
Background Solute carrier family 7 member 11 (SLC7A11) is a component of
cysteine/glutamate transporter, which plays a key role in tumor growth; however, its …
cysteine/glutamate transporter, which plays a key role in tumor growth; however, its …
SLC7A11/xCT is a target of miR-5096 and its restoration partially rescues miR-5096-mediated ferroptosis and anti-tumor effects in human breast cancer cells
Breast cancer cells evade cell death by overexpressing SLC7A11, which functions by
transporting cystine into cells in exchange for intracellular glutamate facilitating glutathione …
transporting cystine into cells in exchange for intracellular glutamate facilitating glutathione …