Ferroptosis is a lipid peroxidation-dependent cell death caused by metabolic dysfunction.
Ferroptosis-associated enzymes are promising therapeutic targets for cancer treatment …

Pancreatic ductal adenocarcinoma (PDAC) cells have a great demand for nutrients in the
form of sugars, amino acids, and lipids. Particularly, amino acids are critical for cancer …

T cell-invigorating cancer immunotherapies have near-curative potential. However, their
clinical benefit is currently limited, as only a fraction of patients respond, suggesting that …

Inducers of ferroptosis such as the glutathione depleting agent Erastin and the GPX4
inhibitor Rsl-3 are being actively explored as potential therapeutics in various cancers, but …

Abstract SLC12A5, a neuron-specific potassium-chloride co-transporter, has been reported
to promote tumor progression, however, the underlying mechanism remains unclear. Here …

As noted by Warburg, many cancer cells depend on the consumption of glucose. We
performed a genetic screen to identify factors responsible for glucose addiction and …

Glioma is the most common malignant primary brain tumor. Its rapid growth is aided by
tumor-mediated glutamate release, creating peritumoral excitotoxic cell death and vacating …

Abstract System xc− contributes to glutathione (GSH) synthesis and protects cells against
ferroptosis by importing cystine and exchanging it with glutamate. Transforming growth …

Background Solute carrier family 7 member 11 (SLC7A11) is a component of
cysteine/glutamate transporter, which plays a key role in tumor growth; however, its …

Breast cancer cells evade cell death by overexpressing SLC7A11, which functions by
transporting cystine into cells in exchange for intracellular glutamate facilitating glutathione …