Androgens are essential to normal prostate growth and development. It is therefore possible
that polymorphisms in the androgen synthesis gene 5α-reductase type II (SRD5A2) may be …

Prostate cancer is the most common malignancy in males and is the second most common
cause of cancer mortality in American men. Polymorphisms have been identified in two …

Steroid hormones, especially testosterone, play important roles in the carcinogenesis of
prostate cancer, and several studies have reported changes in risk with polymorphisms of …

Objectives: Ethnic differences in prostate cancer incidence are well documented, with
African-Americans having among the highest rates in the world. Ethnic differences in …

BACKGROUND Cytosine‐adenine‐guanine repeat length of the androgen receptor gene
and the A49T and V89L polymorphisms of the 5α‐reductase (SRD5A2) gene have been …

BACKGROUND: The relationship between inherited germ-line variations in the 5α-
reductase pathways of androgen biosynthesis and the risk of biochemical recurrence (BCR) …

Purpose: Common treatments for benign prostatic hyperplasia include 5α-reductase
inhibitors and α-adrenergic receptor antagonists. However, these treatments can only …

Testosterone is converted to 5 α‐dihydrotestosterone (DHT) by 5 α‐reductase enzyme,
which is encoded by the SRD5A2 gene. DHT is the main androgen responsible for prostate …

BACKGROUND Prostate cancer is highly influenced by androgens and genes. The authors
investigated whether genetic polymorphisms along the androgen biosynthesis and …

BACKGROUND The aim of this study was to assess the impact of polymorphisms of three
genes within the androgen pathway on prostate volume, clinical parameters, and endocrine …