Ketamine produces rapid and robust antidepressant effects in depressed patients within
hours of administration, often when traditional antidepressant compounds have failed to …

Human studies examining the effects of the dissociative anesthetic ketamine as a model for
psychosis and as a rapidly acting antidepressant have spurred great interest in …

The N-methyl-D-aspartate (NMDA) receptor antagonist ketamine is one of the most attractive
antidepressants since this drug causes rapid-onset and sustained antidepressant effects in …

Ketamine is a racemic mixture of (S)-and (R)-ketamine. The (S)-ketamine enantiomer (Ki 5
465 nM) has an approximately threefold greater affinity for the NMDA receptor relative to (R) …

Background: Ketamine has been reported to exert rapid and sustained antidepressant
effects in patients with depression, including patients with treatment-resistant depression …

Although the robust antidepressant effects of the N-methyl-d-aspartate receptor (NMDAR)
antagonist ketamine in patients with treatment-resistant depression are beyond doubt, the …

The molecular mechanisms underlying major depressive disorder remain poorly
understood, and current antidepressant treatments have many shortcomings. The recent …

Ketamine, a non-competitive antagonist of N-methyl-D-aspartate (NMDA) receptor, displays
a fast antidepressant activity in treatment-resistant depression and in rodent models of …

Recent reports of a rapid antidepressant effect of the glutamate N‐methyl‐d‐aspartate
(NMDA) receptor antagonist ketamine, even in treatment‐resistant populations, have …

Clinical studies have demonstrated that a single sub-anesthetic dose of the dissociative
anesthetic ketamine induces rapid and sustained antidepressant actions. Although this …