Advances in understanding the immunopathology of sarcoidosis and implications on therapy

F Cinetto, C Agostini - Expert review of clinical immunology, 2016 - Taylor & Francis
Introduction: Sarcoidosis is a multi-systemic granulomatous disease of unknown aetiology.
Ethnicity and environmental factors may influence disease incidence, phenotype and …

Immunology of sarcoidosis: old companions, new relationships

F Cinetto, R Scarpa, A Dell'Edera… - Current Opinion in …, 2020 - journals.lww.com
Evidence points at microenvironment and cell functional features rather than cell
polarization or differentiation as determinants of pathogenesis. In terms of therapeutic …

The immunology of sarcoidosis

AK Gerke, G Hunninghake - Clinics in chest medicine, 2008 - Elsevier
Sarcoidosis continues to be a disease of research interest because of its complicated
immune mechanisms and elusive etiology. So far, it has been established that …

[HTML][HTML] A primer on the clinical aspects of sarcoidosis for the basic and translational scientist

MA Judson - Journal of Clinical Medicine, 2021 - mdpi.com
The immunopathogenesis of sarcoidosis remains unclear. This failure in understanding has
been clinically impactful, as it has impeded the accurate diagnosis, treatment, and …

Diagnostic criteria for sarcoidosis

R Heinle, C Chang - Autoimmunity reviews, 2014 - Elsevier
Sarcoidosis is a multiorgan system disease that often presents insidiously. The diagnosis is
often made fortuitously upon routine chest radiography or that done for other reasons …

Sarcoidosis—scientific progress and clinical challenges

ES Chen, DR Moller - Nature Reviews Rheumatology, 2011 - nature.com
Sarcoidosis is an uncommon systemic inflammatory disorder characterized by noncaseating
granulomatous inflammation that most commonly affects the lungs, intrathoracic lymph …

New concepts in the pathogenesis of sarcoidosis

D Bennett, E Bargagli, RM Refini… - Expert Review of …, 2019 - Taylor & Francis
Introduction: The pathogenesis of sarcoidosis is not yet completely understood, although in
recent years our knowledge has made considerable progress. Areas covered: This review …

[HTML][HTML] Biomarkers and molecular endotypes of sarcoidosis: lessons from omics and non-omics studies

HL Ji, NMS Xi, C Mohan, X Yan, KG Jain… - Frontiers in …, 2024 - frontiersin.org
Sarcoidosis is a chronic granulomatous disorder characterized by unknown etiology,
undetermined mechanisms, and non-specific therapies except TNF blockade. To improve …

Aetiopathogenesis, molecular determinants and immunological features

P Spagnolo, J Grunewald - Sarcoidosis, 2022 - books.google.com
In the last decade, our knowledge of sarcoidosis pathobiology has improved substantially,
yet its aetiology remains elusive. Immunological features of sarcoidosis include, among …

Etiology of sarcoidosis

ES Chen, DR Moller - Clinics in chest medicine, 2008 - Elsevier
Research over the past decade has advanced our understanding of the pathogenesis of
sarcoidosis and provided new insights into potential causes of this disease. It is important to …