Discontinuation of drug intake in cocaine abusers commonly produces a variety of adverse
withdrawal symptoms among which anxiety and depression-related behavior are prevailing …

Cocaine is used worldwide and considered a public health problem. Relapse from addiction
is one of the difficulties faced by cocaine users, and in most cases according to the period of …

The initial termination of cocaine consumption in human addicts is associated with
heightened anxiety states and low levels of craving. Craving, however, tends to increase …

Rationale Although high anxiety is commonly associated with drug addiction, its causal role
in this disorder is unclear. Objectives In light of strong evidence for dissociable neural …

Intermittent administration of cocaine can result in behavioral sensitization, which is
indicated by an augmented behavioral response to a subsequent administration of cocaine …

The present study tested the hypothesis that separate neural substrates mediate cocaine
relapse elicited by drug-associated contextual stimuli vs explicit conditioned stimuli (CSs) …

The comorbidity between cocaine use disorder (CUD) and trauma/stressor-related disorders
suggests a connection between neurophysiological changes induced by stress and those …

Cocaine addiction is a chronic, relapsing disorder. Stress and cues related to cocaine are
two common relapse triggers. We have recently shown that exposure to repeated restraint …

Background Long-term cocaine exposure leads to dysregulation of the reward system and
initiates processes that ultimately weaken its rewarding effects. Here, we studied the …

The identification of behavioral traits that could predict an individual's susceptibility to
engage in cocaine addiction is relevant for understanding and preventing this disorder, but …