Advances in sequencing technology have led to the increased availability of genomes and
metagenomes, which has greatly facilitated microbial pan-genome and metagenome …

While comparative bacterial genomic studies commonly predict a set of genes indicative of
common ancestry, experimental validation of the existence of this core genome requires …

Background In the recent years, genomic and pan-genomic studies have become
increasingly important. Culturomics allows to study human microbiota through the use of …

Since the early days of the genome era, the scientific community has relied on a single
'reference'genome for each species, which is used as the basis for a wide range of genetic …

Population genomics of prokaryotes has been studied in depth in only a small number of
primarily pathogenic bacteria, as genome sequences of isolates of diverse origin are lacking …

Background Rapid annotation and comparisons of genomes from multiple isolates (pan-
genomes) is becoming commonplace due to advances in sequencing technology. Genome …

Background The gene content of a species largely governs its ecological interactions and
adaptive potential. A species is therefore defined by both core genes shared between all …

There is an increasing availability of complete or draft genome sequences for microbial
organisms. These data form a potentially valuable resource for genotype–phenotype …

Background A pan-genome is defined as the set of all unique gene families found in one or
more strains of a prokaryotic species. Due to the extensive within-species diversity in the …

Microbial communities might include distinct lineages of closely related organisms that
complicate metagenomic assembly and prevent the generation of complete metagenome …