Deregulation of the HOXA9/MEIS1 axis in acute leukemia
CT Collins, JL Hess - Current opinion in hematology, 2016 - journals.lww.com
HOXA9 deregulation underlies a large subset of aggressive acute leukemias.
Understanding the mechanisms regulating the expression and activity of HOXA9, along with …
Understanding the mechanisms regulating the expression and activity of HOXA9, along with …
Molecular regulators of HOXA9 in acute myeloid leukemia
Dysregulation of the oncogenic transcription factor HOXA9 is a prominent feature for most
aggressive acute myeloid leukemia cases and a strong indicator of poor prognosis in …
aggressive acute myeloid leukemia cases and a strong indicator of poor prognosis in …
Role of HOXA9 in leukemia: dysregulation, cofactors and essential targets
CT Collins, JL Hess - Oncogene, 2016 - nature.com
HOXA9 is a homeodomain-containing transcription factor that has an important role in
hematopoietic stem cell expansion and is commonly deregulated in acute leukemias. A …
hematopoietic stem cell expansion and is commonly deregulated in acute leukemias. A …
[HTML][HTML] HoxA9 regulated Bcl-2 expression mediates survival of myeloid progenitors and the severity of HoxA9-dependent leukemia
G Brumatti, M Salmanidis, CH Kok, RA Bilardi… - Oncotarget, 2013 - ncbi.nlm.nih.gov
Deregulated expression of Hox genes such as HoxA9 is associated with development of
myeloproliferative disorders and leukemia and indicates a poor prognosis. To investigate …
myeloproliferative disorders and leukemia and indicates a poor prognosis. To investigate …
HOXA9 is required for survival in human MLL-rearranged acute leukemias
J Faber, AV Krivtsov, MC Stubbs… - Blood, The Journal …, 2009 - ashpublications.org
Leukemias that harbor translocations involving the mixed lineage leukemia gene (MLL)
possess unique biologic characteristics and often have an unfavorable prognosis. Gene …
possess unique biologic characteristics and often have an unfavorable prognosis. Gene …
HOXA9 reprograms the enhancer landscape to promote leukemogenesis
Aberrant expression of HOXA9 is a prominent feature of acute leukemia driven by diverse
oncogenes. Here we show that HOXA9 overexpression in myeloid and B progenitor cells …
oncogenes. Here we show that HOXA9 overexpression in myeloid and B progenitor cells …
C/EBPα is an essential collaborator in Hoxa9/Meis1-mediated leukemogenesis
Homeobox A9 (HOXA9) is a homeodomain-containing transcription factor that plays a key
role in hematopoietic stem cell expansion and is commonly deregulated in human acute …
role in hematopoietic stem cell expansion and is commonly deregulated in human acute …
Protein kinase C-mediated phosphorylation of the leukemia-associated HOXA9 protein impairs its DNA binding ability and induces myeloid differentiation
U Vijapurkar, N Fischbach, W Shen… - … and cellular biology, 2004 - Taylor & Francis
HOXA9 expression is a common feature of acute myeloid leukemia, and high-level
expression is correlated with poor prognosis. Moreover, HOXA9 overexpression …
expression is correlated with poor prognosis. Moreover, HOXA9 overexpression …
[HTML][HTML] HOXA/PBX3 knockdown impairs growth and sensitizes cytogenetically normal acute myeloid leukemia cells to chemotherapy
GJ Dickson, FG Liberante, LM Kettyle… - …, 2013 - ncbi.nlm.nih.gov
The cytogenetically normal subtype of acute myeloid leukemia is associated with an
intermediate risk which complicates therapeutic options. Lower overall HOX/TALE …
intermediate risk which complicates therapeutic options. Lower overall HOX/TALE …
Direct and indirect targeting of HOXA9 transcription factor in acute myeloid leukemia
M Lambert, M Alioui, S Jambon, S Depauw… - Cancers, 2019 - mdpi.com
HOXA9 (Homeobox A9) is a homeotic transcription factor known for more than two decades
to be associated with leukemia. The expression of HOXA9 homeoprotein is associated with …
to be associated with leukemia. The expression of HOXA9 homeoprotein is associated with …