Wnt signaling has recently emerged as a critical pathway in lung carcinogenesis as already
demonstrated in many cancers and particularly in colorectal cancer. We critically discuss in …

Wnt/β-catenin alterations are prominent in human malignancies. In non–small cell lung
cancer (NSCLC), β-catenin and APC mutations are uncommon, but Wnt signaling is …

Since the initial discovery of the oncogenic activity of WNT ligands our understanding of the
complex roles for WNT signaling pathways in lung cancers has increased substantially. In …

The Wnt pathway plays an important role in development and in regulating adult stem cell
systems. A variety of cellular processes is mediated by Wnt signaling, which includes …

Evidence suggests that stem cells may be the source of mutant cells that cause cancers to
develop and proliferate. Wnt signaling has been shown to promote self-renewal in gut …

Lung cancer is the most common cause of cancer mortality worldwide. Non-small-cell lung
carcinomas (NSCLCs), which represent around 80% of lung tumors, exhibit poor prognosis …

Non small cell lung cancer (NSCLC) is the leading cause of cancer deaths in the United
States and worldwide. Unfortunately, standard therapies remain inadequate. An increased …

The WNT family of signaling proteins is essential to organ development in general and lung
morphogenesis in particular. Originally identified as a developmentally active signaling …

BACKGROUND: The Wnt gene family is involved in embryogenesis and tumourigenesis. We
investigated the clinical significance of Wnt1 expression in non-small cell lung cancer …

The WNT signalling cascades have emerged as critical regulators of a wide variety of
biological aspects involved in lung development as well as in physiological and …