Background Neuropeptides play a critical role in regulating pain and inflammation. Despite
accumulating evidence has further uncovered the novel functions and mechanisms of …

Peptides released from trigeminal fibers fulfill well-understood functions in
neuroinflammatory processes and in the modulation of nociceptive signal processing. In …

Objective This systematic review aims to explore the changes in expression of
neuropeptides and/or their receptors following experimental trigeminal neuropathic pain in …

This review highlights potential molecular targets for treating neuropathic orofacial pain
based on current findings in animal models. Preclinical research is currently elucidating the …

Calcitonin gene-related peptide (CGRP) plays a crucial role in the modulation of orofacial
pain, and we hypothesized that CGRP mediated a neuron-glia crosstalk in orofacial pain …

Orofacial pain represents a multidisciplinary biomedical challenge involving basic and
clinical research for which no satisfactory solution has been found. In this regard, trigeminal …

Clinical and basic research on regulation of pituitary hormones, extra-pituitary release of
these hormones, distribution of their receptors and cell signaling pathways recruited upon …

While effective therapies are available for some types of craniofacial pain, treatments for
deep-tissue craniofacial pain such as temporomandibular disorders are less efficacious …

It is generally accepted that the nervous system contributes to the pathophysiology of
peripheral inflammation, and a neurogenic component has been implicated in many …

Background Pain is a warning signal for the body defense mechanisms and is a critical
sensation for supporting life. However, there are still many unclear points about the …