Patients with peripheral arterial disease (PAD) suffer from impaired muscle function due to
insufficient oxygen supply during exercise, mitochondrial damages, unfavourable muscle …

BACKGROUND: The treadmill exercise test is the most important examination of the
functional ability of patients with intermittent claudication or leg pain during exercise, but it …

Background 31P-MR spectroscopy is a technique for undertaking a comprehensive
evaluation of muscle metabolism. The goal of this study was to compare patients with mild …

According to the literature the steady-state level of phosphocreatine (PCr) has a linear
relationship to the workload during muscle exercise intensities below the lactate threshold …

Objective: Decreased oxygen supply is generally accepted as the primary cause of muscle
dysfunction in patients with peripheral arterial occlusive disease (PAOD) and intermittent …

RATIONALE AND OBJECTIVES. The aim of the authors' prospective study was to explore
therapy-induced changes of muscular metabolism in arterial occlusive disease (AOD) …

BACKGROUND: The purpose of this study was to investigate phosphocreatine (PCr) and
inorganic phosphate levels as well as pH changes in exercising muscle at a workload of 4.5 …

Several previous 31 phosphorus magnetic resonance spectroscopy (31P MRS) studies
performing incremental or progressive muscle exercises have observed that a decrease in …

Background Clinical assessments of peripheral artery disease (PAD) severity are insensitive
to pathophysiological changes in muscle tissue oxygenation and energy metabolism distal …

Phosphorous magnetic resonance spectroscopy (31P MRS) is a unique tool to investigate in
vivo high-energy phosphates (HEP) in the human heart. We hypothesized that physical …