Senescent cells can drive age-related tissue dysfunction partially via a senescence-
associated secretory phenotype (SASP) involving proinflammatory and profibrotic factors …

Cellular senescence is a complicated process featured by irreversible cell cycle arrest and
senescence-associated secreted phenotype (SASP), resulting in accumulation of senescent …

Lung function declines as people age and their lungs become stiffer. With an increasing
elderly population, understanding mechanisms that contribute to these structural and …

Cellular senescence is a state of permanent cell cycle arrest triggered by various intrinsic
and extrinsic stressors. Cellular senescence results in impaired tissue repair and …

Cellular senescence results in cell cycle arrest with secretion of cytokines, chemokines,
growth factors, and remodeling proteins (senescence-associated secretory phenotype; …

Asthma is a heterogeneous chronic respiratory disease that impacts nearly 10% of the
population worldwide. While cellular senescence is a normal physiological process, the …

Chronic obstructive pulmonary disease (COPD) is characterized by unrelenting airway
inflammation, loss of alveolar-capillary units, and a progressive decline in lung function …

Cellular senescence, a characteristic sign of aging, classically refers to permanent cell
proliferation arrest and is a vital contributor to the pathogenesis of cancer and age-related …

Small airway disease (SAD) is a key early-stage pathology of chronic obstructive pulmonary
disease (COPD). COPD is associated with cellular senescence whereby cells undergo …

Prevalence of asthma in older adults is growing along with increasing global life expectancy.
Due to poor clinical consequences such as high mortality, advancement in understanding …