Sodium iodide symporter (NIS) in extrathyroidal malignancies: focus on breast and urological cancer

S Micali, S Bulotta, C Puppin, A Territo, M Navarra… - BMC cáncer, 2014 - Springer
Background Expression and function of sodium iodide symporter (NIS) is requisite for
efficient iodide transport in thyrocytes, and its presence in cancer cells allows the use of …

Sodium iodide symporter-based strategies for diagnosis and treatment of thyroidal and nonthyroidal malignancies

AE Heufelder, N Morgenthaler, ML Schipper, W Joba - Thyroid, 2001 - liebertpub.com
The recent cloning and molecular characterization of the sodium iodide-symporter (NIS) has
inspired novel approaches to the diagnosis and treatment of thyroidal and nonthyroidal …

The sodium iodide symporter: its pathophysiological and therapeutic implications

C Spitzweg, JC Morris - Clinical endocrinology, 2002 - Wiley Online Library
The sodium iodide symporter (NIS) is an intrinsic plasma membrane protein that mediates
the active transport of iodide in the thyroid gland and a number of extrathyroidal tissues, in …

The sodium-iodide symporter. Pathophysiologic, diagnostic and therapeutic significance

C Spitzweg - Der Internist, 2003 - europepmc.org
The sodium iodide symporter NIS) is an intrinsic plasma membrane protein that mediates
the active transport of iodide in the thyroid gland and a number of extrathyrioidal tissues, in …

Sodium iodide symporter in health and disease

DHY Shen, RT Kloos, EL Mazzaferri, SM Jhiang - Thyroid, 2001 - liebertpub.com
Radioiodine-concentrating activity in thyroid tissues has allowed the use of radioiodine as a
diagnostic and therapeutic agent for patients with thyroid disorders such as well …

Immunoanalysis indicates that the sodium iodide symporter is not overexpressed in intracellular compartments in thyroid and breast cancers

I Peyrottes, V Navarro, A Ondo-Mendez… - European journal of …, 2009 - academic.oup.com
Objective The active transport of iodide into thyroid cells is mediated by the Na+/I− symporter
(NIS) located in the basolateral membrane. Strong intracellular staining with anti-NIS …

Enhancement of sodium/iodide symporter expression in thyroid and breast cancer

T Kogai, K Taki, GA Brent - Endocrine-Related Cancer, 2006 - erc.bioscientifica.com
The sodium/iodide symporter (NIS) mediates iodide uptake in the thyroid gland and lactating
breast. NIS mRNA and protein expression are detected in most thyroid cancer specimens …

Sodium iodide symporter: its role in nuclear medicine

JK Chung - Journal of nuclear medicine, 2002 - Soc Nuclear Med
Thyroid iodide uptake is basic to the clinical applications of radioiodine. Iodide uptake
occurs across the membrane of the thyroid follicular cells through an active transporter …

A perspective view of sodium iodide symporter research and its clinical implications

G Riesco-Eizaguirre… - European Journal of …, 2006 - academic.oup.com
The sodium iodide symporter (NIS) is an intrinsic plasma membrane protein that mediates
active iodide transport into the thyroid gland and into several extrathyroidal tissues, in …

The complex regulation of NIS expression and activity in thyroid and extrathyroidal tissues

G Riesco-Eizaguirre, P Santisteban… - Endocrine-Related …, 2021 - erc.bioscientifica.com
The sodium iodide symporter (NIS) is an intrinsic plasma membrane protein that mediates
active iodide transport into the thyroid gland and into several extrathyroidal tissues. NIS …