Chlamydia trachomatis plasmid-encoded protein pORF5 protects mitochondrial function by inducing mitophagy and increasing HMGB1 expression

W Lei, Q Li, S Su, J Bu, Q Huang, Z Li - Pathogens and disease, 2017 - academic.oup.com
Chlamydia trachomatis, an obligate intracellular pathogen, has various effective strategies to
regulate host cell death signalling pathways that ensure completion of their growth cycle …

Chlamydia trachomatis targets mitochondrial dynamics to promote intracellular survival and proliferation

Y Kurihara, R Itoh, A Shimizu, NF Walenna… - Cellular …, 2019 - Wiley Online Library
Chlamydia trachomatis is an obligate intracellular bacterium that scavenges host metabolic
products for its replication. Mitochondria are the power plants of eukaryotic cells and provide …

Chlamydia trachomatis pORF5 plasmid-encoded protein regulates autophagy and apoptosis of HeLa cells

B He, Y Zhao, X Yang, S Su, Y Wen… - Biotechnology & …, 2019 - Taylor & Francis
Chlamydia trachomatis is an important human pathogen responsible for a variety of
important diseases. pORF5, a plasmid protein in C. trachomatis, has been reported to …

LncRNA ZEB1-AS1/miR-1224-5p / MAP4K4 axis regulates mitochondria-mediated HeLa cell apoptosis in persistent Chlamydia trachomatis infection

F Luo, Y Wen, L Zhao, S Su, W Lei, L Chen, C Chen… - Virulence, 2022 - Taylor & Francis
Persistent infection of Chlamydia trachomatis is thought to be responsible for the debilitating
sequelae of blinding trachoma and infertility. Inhibition of host cell apoptosis is a persistent …

Chlamydia trachomatis alters mitochondrial protein composition and secretes effector proteins that target mitochondria

Z Dimond, LD Bauler, Y Zhang, A Carmody… - Msphere, 2022 - Am Soc Microbiol
Mitochondria are critical cellular organelles that perform a wide variety of functions,
including energy production and immune regulation. To perform these functions …

Chlamydia preserves the mitochondrial network necessary for replication via microRNA-dependent inhibition of fission

SR Chowdhury, A Reimer, M Sharan… - Journal of Cell …, 2017 - rupress.org
Obligate intracellular bacteria such as Chlamydia trachomatis depend on metabolites of the
host cell and thus protect their sole replication niche by interfering with the host cells' stress …

[HTML][HTML] Insights into mitochondrial dynamics in chlamydial infection

Y Yang, W Lei, L Zhao, Y Wen, Z Li - Frontiers in Cellular and Infection …, 2022 - frontiersin.org
Mitochondria are involved in the creation of cellular energy, material metabolism, apoptosis,
and intrinsic immunity. Mitochondria, being an organelle with an extraordinarily high degree …

Chlamydia trachomatis induces lncRNA MIAT upregulation to regulate mitochondria‐mediated host cell apoptosis and chlamydial development

F Luo, Y Wen, L Zhao, S Su, Y Zhao… - Journal of cellular and …, 2022 - Wiley Online Library
Chlamydia trachomatis persistent infection is the leading cause of male prostatitis and
female genital tract diseases. Inhibition of host cell apoptosis is the key to maintaining …

Chlamydia trachomatis plasmid-encoded protein pORF5 activates unfolded protein response to induce autophagy via MAPK/ERK signaling pathway

Y Wen, F Luo, Y Zhao, S Su, M Shu, Z Li - Biochemical and biophysical …, 2020 - Elsevier
Chlamydia trachomatis (C. trachomatis) is an obligate intracellular organism that depends
on nutrients from the host cell for their replication and proliferation. Therefore, the interaction …

[HTML][HTML] Growth of Chlamydia pneumoniae Is Enhanced in Cells with Impaired Mitochondrial Function

N Käding, I Kaufhold, C Müller, M Szaszak… - Frontiers in Cellular …, 2017 - frontiersin.org
Effective growth and replication of obligate intracellular pathogens depend on host cell
metabolism. How this is connected to host cell mitochondrial function has not been studied …