Microsatellite instability (MSI) refers to the biochemical detection of frameshifted
microsatellite sequences from genomic DNA. Genesis of MSI is due to defective DNA …

DNA mismatch repair (MMR) function is critical for correcting errors coincident with
polymerase-driven DNA replication, and its proteins are frequent targets for inactivation …

Several forms of genomic instability are known to drive the development of colorectal cancer
(CRC). Chromosomal instability is the most common type found in 85% of the CRC, while …

Microsatellite instability (MSI) is the molecular fingerprint of a deficient mismatch repair
system. Approximately 15% of colorectal cancers (CRC) display MSI owing either to …

Simple Summary A deficient mismatch repair system (dMMR) results in microsatellite
instability (MSI). The MSI status of a tumor predicts the response to immune checkpoint …

Microsatellite instability (MSI) is a key biomarker in colorectal cancer (CRC), with crucial
diagnostic, prognostic, and predictive implications. Testing for mismatch repair deficiency …

Microsatellite instability (MSI), the somatic accumulation of length variations in repetitive
DNA sequences called microsatellites, is frequently observed in both hereditary and …

Background Microsatellite instability (MSI) constitutes an important oncogenic molecular
pathway in colorectal cancer (CRC), representing approximately 15% of all colorectal …

Colorectal cancer (CRC) is the third most common cancer worldwide. In the past decade,
mismatch repair deficiency (dMMR), manifested as microsatellite instability-high (MSI-H) …

Microsatellite instability (MSI) is the molecular fingerprint of the deficient mismatch repair
(MMR) system, which characterizes∼ 15% of colorectal cancers. MSI develops as a result of …