Cellular immune activation in cerebrospinal fluid from Ugandans with cryptococcal meningitis and immune reconstitution inflammatory syndrome
Background. Human immunodeficiency virus (HIV)-associated cryptococcal meningitis (CM)
is characterized by high fungal burden and limited leukocyte trafficking to cerebrospinal fluid …
is characterized by high fungal burden and limited leukocyte trafficking to cerebrospinal fluid …
Immune reconstitution inflammatory syndrome in HIV-associated cryptococcal meningitis: a prospective study
T Bicanic, G Meintjes, K Rebe, A Williams… - JAIDS Journal of …, 2009 - journals.lww.com
Background: Prospective data on incidence, characteristics, and risk factors for cryptococcal
meningitis immune reconstitution inflammatory syndrome (CM-IRIS) are lacking. Methods …
meningitis immune reconstitution inflammatory syndrome (CM-IRIS) are lacking. Methods …
Hiv-associated cryptococcal immune reconstitution inflammatory syndrome is associated with aberrant t cell function and increased cytokine responses
Cryptococcal meningitis remains a significant opportunistic infection among HIV-infected
patients, contributing 15–20% of HIV-related mortality. A complication of initiating …
patients, contributing 15–20% of HIV-related mortality. A complication of initiating …
Paucity of initial cerebrospinal fluid inflammation in cryptococcal meningitis is associated with subsequent immune reconstitution inflammatory syndrome
DR Boulware, SC Bonham, DB Meya… - The Journal of …, 2010 - academic.oup.com
Abstract Background. Cryptococcal meningitis (CM)-related immune reconstitution
inflammatory syndrome (IRIS) complicates antiretroviral therapy (ART) in 20%–40% of ART …
inflammatory syndrome (IRIS) complicates antiretroviral therapy (ART) in 20%–40% of ART …
Monocyte phenotype and IFN-γ-inducible cytokine responses are associated with cryptococcal immune reconstitution inflammatory syndrome
A third of adults with AIDS and cryptococcal meningitis (CM) develop immune reconstitution
inflammatory syndrome (IRIS) after initiating antiretroviral therapy (ART), which is thought to …
inflammatory syndrome (IRIS) after initiating antiretroviral therapy (ART), which is thought to …
The CSF Immune Response in HIV-1–Associated Cryptococcal Meningitis: Macrophage Activation, Correlates of Disease Severity, and Effect of Antiretroviral Therapy
JE Scriven, LM Graham, C Schutz… - JAIDS Journal of …, 2017 - journals.lww.com
Background: Immune modulation may improve outcome in HIV-associated cryptococcal
meningitis. Animal studies suggest alternatively activated macrophages are detrimental but …
meningitis. Animal studies suggest alternatively activated macrophages are detrimental but …
Cryptococcosis-IRIS is Associated With Lower Cryptococcus-specific IFN-γ Responses Before Antiretroviral Therapy but Not Higher T-Cell Responses During …
CC Chang, A Lim, S Omarjee, SM Levitz… - The Journal of …, 2013 - academic.oup.com
Background. Cryptococcosis-associated immune reconstitution inflammatory syndrome (C-
IRIS) may be driven by aberrant T-cell responses against cryptococci. We investigated this in …
IRIS) may be driven by aberrant T-cell responses against cryptococci. We investigated this in …
Compartmentalization of innate immune responses in the central nervous system during cryptococcal meningitis/HIV coinfection
V Naranbhai, CC Chang, R Durgiah, S Omarjee, A Lim… - Aids, 2014 - journals.lww.com
Objective: The role of innate immunity in the pathogenesis of cryptococcal meningitis is
unclear. We hypothesized that natural killer (NK) cell and monocyte responses show central …
unclear. We hypothesized that natural killer (NK) cell and monocyte responses show central …
Plasma but not cerebrospinal fluid interleukin 7 and interleukin 5 levels pre–antiretroviral therapy commencement predict cryptococcosis-associated immune …
NA Akilimali, CC Chang, DM Muema… - Clinical Infectious …, 2017 - academic.oup.com
Background Patients with human immunodeficiency virus/AIDS-associated cryptococcal
meningitis (CM) frequently experience clinical deterioration, known as cryptococcosis …
meningitis (CM) frequently experience clinical deterioration, known as cryptococcosis …
Chemokine levels and chemokine receptor expression in the blood and the cerebrospinal fluid of HIV-infected patients with cryptococcal meningitis and …
CC Chang, S Omarjee, A Lim, T Spelman… - The Journal of …, 2013 - academic.oup.com
Background. Human immunodeficiency virus–infected patients with treated cryptococcal
meningitis who start combination antiretroviral therapy (cART) are at risk of further …
meningitis who start combination antiretroviral therapy (cART) are at risk of further …
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