In addition to the known preventive effects of environmental enrichment (EE) on drug
addiction, we have recently shown that EE can also have “curative” effects and eliminate …

Whereas earlier studies have focused on the preventive effects of enriched environments
(EE) in drug addiction, in a recent study we suggested that EE can also have …

Environmental conditions can dramatically influence the behavioral and neurochemical
effects of drugs of abuse. For example, stress increases the reinforcing effects of drugs and …

The development and maintenance of cocaine addiction depend heavily on learned reward-
environment associations that can induce drug-seeking behavior and relapse …

Background Addiction is a chronic disease characterized by persistent vulnerability to
relapse during abstinence. In animal models of addiction, accumulating evidence suggests …

Previous research suggests that the prelimbic subregion of the medial prefrontal cortex
(mPFC) is necessary for acquisition of cocaine-conditioned place preference (CPP) …

We hypothesized that environmental enrichment in rats may reduce cocaine-seeking
behaviour elicited by cocaine-priming injections and by cocaine-associated cues. Rats …

Cocaine treatment paired with environmental cues establishes a conditioned place
preference (CPP) for that environment. After expression of this preference, rats show …

Recent studies have demonstrated that exposure to environmental enrichment (EE) during
withdrawal periods reduces the risks of relapse to drug-seeking behavior. In this study, we …

Background: Substance use disorder emerges in a small proportion of drug users and has
the characteristics of a chronic relapsing pathology. Aims: Our study aimed to demonstrate …