Deposition of β-amyloid (Aβ) is a characteristic feature of the pathology of Alzheimer's
disease (AD). Since glucose metabolism and the consequential ATP production are …

In the present study, we examined whether the relative levels of regional brain [14C] 2-
deoxyglucose (2-DG) uptake are altered in a transgenic mouse model of Alzheimer's …

Reduced glucose metabolism and formation of polyglucosan bodies (PGB) are, beside
amyloid beta plaques and neurofibrillary tangles, well‐known pathological findings …

Amyloid precursor protein (APP) gene encodes the short peptide fragment amyloid-beta-
protein present in senile plaque cores, cerebrovascular amyloid, and intracellular …

Alzheimer's disease (AD) is the most common form of dementia in the elderly. Accumulation
of Aβ peptides in the brain has been suggested as the cause of AD (amyloid cascade …

Amyloid peptides that aggregate to form plaques in Alzheimer's disease are derived from
secretory processing of the amyloid precursor protein (APP). Transport of APP to the cell …

Abnormal metabolic processing of the beta/A4 amyloid precursor protein (APP) has been
implicated in the pathogenesis of Alzheimer disease. Several aspects of normal APP …

Increased production of amyloid β peptide (Aβ) is highly suspected to play a major role in
Alzheimer's disease (AD) pathogenesis. Because Aβ deposits in AD senile plaques appear …

Background Although increasing evidence has indicated that brain insulin dysfunction is a
risk factor for Alzheimer disease (AD), the underlying mechanisms by which insulin …

Preischemic hyperglycemia is known to accentuate acute ischemic injury to neurons,
microglia, and endothelia. In the present study, we used a monoclonal antibody to the N …