[HTML][HTML] Murine models of atrophy, cachexia, and sarcopenia in skeletal muscle

M Romanick, LDV Thompson… - Biochimica et Biophysica …, 2013 - Elsevier
With the extension of life span over the past several decades, the age-related loss of muscle
mass and strength that characterizes sarcopenia is becoming more evident and thus, has a …

[HTML][HTML] Sarcopenia and muscle aging: a brief overview

T Dao, AE Green, YA Kim, SJ Bae… - Endocrinology and …, 2020 - synapse.koreamed.org
The world is facing the new challenges of an aging population, and understanding the
process of aging has therefore become one of the most important global concerns …

Models of accelerated sarcopenia: critical pieces for solving the puzzle of age-related muscle atrophy

TW Buford, SD Anton, AR Judge, E Marzetti… - Ageing research …, 2010 - Elsevier
Sarcopenia, the age-related loss of skeletal muscle mass, is a significant public health
concern that continues to grow in relevance as the population ages. Certain conditions have …

Experimental models of sarcopenia: bridging molecular mechanism and therapeutic strategy

S Mankhong, S Kim, S Moon, HB Kwak, DH Park… - Cells, 2020 - mdpi.com
Sarcopenia has been defined as a progressive decline of skeletal muscle mass, strength,
and functions in elderly people. It is accompanied by physical frailty, functional disability …

Age-related dysfunction in proteostasis and cellular quality control in the development of sarcopenia

HG Paez, CR Pitzer, SE Alway - Cells, 2023 - mdpi.com
Sarcopenia is a debilitating skeletal muscle disease that accelerates in the last decades of
life and is characterized by marked deficits in muscle strength, mass, quality, and metabolic …

Molecular and phenotypic analysis of rodent models reveals conserved and species-specific modulators of human sarcopenia

A Börsch, DJ Ham, N Mittal, LA Tintignac… - Communications …, 2021 - nature.com
Sarcopenia, the age-related loss of skeletal muscle mass and function, affects 5–13% of
individuals aged over 60 years. While rodents are widely-used model organisms, which …

Animal models of sarcopenia

CJ Christian, GM Benian - Aging Cell, 2020 - Wiley Online Library
Sarcopenia is the age‐related decline in muscle mass and function without any underlying
disease. The exact molecular mechanisms responsible for this pathology remain unknown …

[HTML][HTML] Molecular mechanisms and therapeutic interventions in sarcopenia

SS Park, ES Kwon, KS Kwon - Osteoporosis and sarcopenia, 2017 - Elsevier
Sarcopenia is the degenerative loss of muscle mass and function with aging. Recently
sarcopenia was recognized as a clinical disease by the International Classification of …

Mouse models of sarcopenia: classification and evaluation

W Xie, M He, D Yu, Y Wu, X Wang, S Lv… - Journal of cachexia …, 2021 - Wiley Online Library
Sarcopenia is a progressive and widespread skeletal muscle disease that is related to an
increased possibility of adverse consequences such as falls, fractures, physical disabilities …

Role and potential mechanisms of anabolic resistance in sarcopenia

PH Haran, DA Rivas, RA Fielding - Journal of cachexia, sarcopenia and …, 2012 - Springer
There is pressing need to understand the aging process to better cope with its associated
physical and societal costs. The age-related muscle wasting known as sarcopenia is a major …