Two-dimensional gel-electrophoretic analysis combined with fluorography and
densitometric quantification was used to examine the effects of glucose on the biosynthesis …

Dense, homogeneous granules of 250 to 350 mµ in diameter have been found inside the
cavities of the endoplasmic reticulum in the acinar cells of the pancreas of the guinea pig …

The electron microscopical changes of the pancreatic islets of rats were studied during the
phase of transient diabetes and during recovery, following a prolonged period of insulin …

Confocal microscopy with Zinquin, a fluorogenic Zn2+-specific indicator, was used for
spatially and temporally resolved measurement of Zn2+ efflux from single pancreatic β-cells …

Calcium plays an important role in the release of insulin. When the GBHA [glyoxal bis (2-
hydroxyanil)] reaction is employed, calcium can be clearly demonstrated by light microscope …

During the past thirty-five years the knowledge of the finer details of the structure of the islets
of Langerhans has been increasing steadily. Laguesse ('95,'06) found that the islet cells …

Pancreatic islet B cell function was studied in vitro using three structurally different
preparations of islet tissues: isolated, intact islets, dispersed islet cells attached singly to …

At physiological glucose concentrations, isolated pancreatic islets release a minor portion of
their newly synthesized insulin and precursors in a phase of secretion which is largely …

Isolated rat pancreatic islets were pulse-labeled for 5 min with [3H] leucine then chased for
25 min, during which time endogenously labeled [3H] proinsulin becomes predominantly …

A zymogen granule fraction has been isolated from rat pancreas, and its purity has been
assessed by biochemical and morphological criteria. Specific activities of two marker …