Induced pluripotent stem cells: what lies beyond the paradigm shift

JL Cox, A Rizzino - Experimental Biology and Medicine, 2010 - journals.sagepub.com
The discovery that somatic cells can be reprogrammed to become induced pluripotent stem
(iPS) cells has ushered in a new and exciting era in regenerative medicine. Since the …

Current advances in the generation of human iPS cells: implications in cell‐based regenerative medicine

A Revilla, C González, A Iriondo… - Journal of tissue …, 2016 - Wiley Online Library
Over the last few years, the generation of induced pluripotent stem cells (iPSCs) from human
somatic cells has proved to be one of the most potentially useful discoveries in regenerative …

[HTML][HTML] Generation of induced pluripotent stem cells from CD34+ cells across blood drawn from multiple donors with non-integrating episomal vectors

AA Mack, S Kroboth, D Rajesh, WB Wang - PloS one, 2011 - journals.plos.org
The methodology to create induced pluripotent stem cells (iPSCs) affords the opportunity to
generate cells specific to the individual providing the host tissue. However, existing methods …

[HTML][HTML] Derivation of induced pluripotent stem cells from human peripheral blood T lymphocytes

ME Brown, E Rondon, D Rajesh, A Mack, R Lewis… - PloS one, 2010 - journals.plos.org
Induced pluripotent stem cells (iPSCs) hold enormous potential for the development of
personalized in vitro disease models, genomic health analyses, and autologous cell …

Harnessing the potential of induced pluripotent stem cells for regenerative medicine

SM Wu, K Hochedlinger - Nature cell biology, 2011 - nature.com
The discovery of methods to convert somatic cells into induced pluripotent stem cells
(iPSCs) through expression of a small combination of transcription factors has raised the …

[HTML][HTML] Optimizing the method for generation of integration-free induced pluripotent stem cells from human peripheral blood

H Gu, X Huang, J Xu, L Song, S Liu, X Zhang… - Stem Cell Research & …, 2018 - Springer
Background Generation of induced pluripotent stem cells (iPSCs) from human peripheral
blood provides a convenient and low-invasive way to obtain patient-specific iPSCs. The …

[HTML][HTML] Induced pluripotent stem cells: paths to new medicines: A catalyst for disease modelling, drug discovery and regenerative therapy

W Deng - EMBO reports, 2010 - embopress.org
The invention of iPSC in 2006 has been heralded as a major breakthrough. Wenbin Deng
explains the enormous potential of these cells for research into human diseases and …

Future perspective of induced pluripotent stem cells for diagnosis, drug screening and treatment of human diseases

Q Lian, Y Chow, MA Esteban, D Pei… - Thrombosis and …, 2010 - thieme-connect.com
Recent advances in stem cell biology have transformed the understanding of cell physiology
and developmental biology such that it can now play a more prominent role in the clinical …

Pluripotency of induced pluripotent stem cells

C Feng, YD Jia, XY Zhao - Genomics, proteomics & …, 2013 - academic.oup.com
Induced pluripotent stem (iPS) cells can be generated by forced expression of four
pluripotency factors in somatic cells. This has received much attention in recent years since …

Human induced pluripotent stem cell (iPSC) handling protocols: Maintenance, expansion, and cryopreservation

D Marotta, C Rao, V Fossati - … Pluripotent Stem (iPS) Cells: Methods and …, 2021 - Springer
Human induced pluripotent stem cells (iPSCs) have emerged as an invaluable resource for
basic research, disease modeling, and drug discovery over recent years. Given the …