BACKGROUND: Several studies have tried to find possible associations between genetic
polymorphisms and inflammatory bowel disease prevalence and/or phenotype. Our …

Ulcerative colitis (UC) and Crohn's disease (CD) are immunologically mediated disorders
characterized by a chronic, relapsing inflammatory response. Elevation of several cytokines …

Objective Inflammatory bowel diseases (IBD) are multifactorial disorders, characterized by
failure to limit the inflammatory response to luminal antigens. Genetic factors play an …

Abstract Background/Aims: Ulcerative colitis and Crohn's disease have well-recognized
familial tendencies, but the genetic basis of this clinical observation remains unknown. The …

Objective: To investigate a polymorphism within intron 2 of the interleukin-1 receptor
antagonist (IL-1 ra) gene in a Dutch white population of patients with ulcerative colitis and …

Genetic linkage analysis in families with multiple cases of inflammatory bowel disease (IBD)
has mapped a gene which confers susceptibility to IBD to the pericentromeric region of …

Imbalances in the regulation of Th1 and Th2 lymphocytes are crucial in inflammatory bowel
diseases. Interleukin-4 is secreted by Th2 lymphocytes and downregulates cytokine …

Objective. Crohn's disease (CD) and ulcerative colitis (UC) are chronic inflammatory
diseases of the bowel, the causes of which are not fully known. Ethnic differences in disease …

Objective. Pathological evidence supports a potential role of the pro-and anti-inflammatory
cytokine network in the pathogenesis of inflammatory bowel disease (IBD). Moreover …

Association studies have identified the interleukin-1 receptor antagonist gene allele 2 (IL-
1RN* 2) as a marker of susceptibility in ulcerative colitis (UC). This study investigated the …