Although the importance of genetic susceptibility to IBD has been established by
epidemiological studies, the genes involved remain poorly characterized. Important …

Abstract Interleukin-4 (IL-4) is an important cytokine in mucosal immunity and plays a critical
role in the development of colitis inT-α cell receptor mutant mice. Functionally significant …

BACKGROUND AND AIMS An association between the allele 2 of the interleukin 1 receptor
antagonist gene variable number tandem repeats polymorphism in intron 2 and ulcerative …

Inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative
colitis (UC), represents a group of chronic inflammatory disorders caused by dysregulated …

Objective An association between polymorphism in the gene coding for the anti-
inflammatory cytokine interleukin-1-receptor antagonist (IL-1Ra) and ulcerative colitis (UC) …

Background: Changes in cytokine expression have been frequently found in patients with
inflammatory bowel disease (IBD). Cytokine values outside the normal range may be …

Background Crohn's disease (CD) and ulcerative colitis (UC), 2 major forms of inflammatory
bowel disease (IBD), are complex disorders with significant genetic predisposition. The first …

BACKGROUND: Concordance rates in siblings and twins provide strong evidence that
genetic susceptibility is important in the pathogenesis of inflammatory bowel disease. The …

Although genetic predisposition for inflammatory bowel disease (IBD) is well established,
little is known about the accountable genes. The pathogenesis of IBD is characterized by an …

Background Ulcerative colitis (UC) is an inflammatory bowel disease of unknown etiology.
Among cytokines induced in UC, interleukin 1 antagonist (IL-1ra) and interleukin 1 β (IL-1β) …