The mechanisms responsible for development of inflammatory bowel disease (IBD) have not
been fully elucidated, although the main cause of disease pathology is attributed to up …

Anti‐inflammatory cytokines have an important role in disease, tumour and transplant
processes. Alterations in the regulation of several cytokines have been implicated in a …

METHODS Cytokine genotyping was performed utilizing polymerase chain reaction. The
specific gene polymorphisms that were probed for included:− 1082 (G/A),− 819 (T/C), and …

The IL-6 gene maps to an area of chromosome 7 known to be significant for susceptibility to
inflammatory bowel disease. The functional effects of interleukin-6 (IL-6) polymorphisms in …

Abstract Interleukin-10 (IL-10) has a key role in regulating mucosal inflammation. The role of
functional polymorphisms at positions− 627 and− 1117 in the IL-10 gene as candidate …

The allelic frequencies of TaqI, PstI, and variable number of tandem repeat (VNTR)
polymorphisms of the IL-1β, IL-1 receptor (IL-1Re), and IL-1 receptor antagonist (IL-1Ra) …

Inflammatory bowel disease (IBD), manifesting as Crohn's disease (CD) and ulcerative
colitis (UC), is characterized by recurring episodes of inflammation in gastrointestinal tract, in …

Interleukin‐10 (IL‐10) is an anti‐inflammatory cytokine. Its production in humans is under
genetic control, and genotype defines high or low producers of this cytokine. This study …

Objective: To test whether IL-10 promoter region polymorphisms are associated with
susceptibility to inflammatory bowel disease, we examined the contribution of interleukin-10 …

Abstract Background and Aim Interleukin (IL)-1 family members play an important role in the
pathogenesis of inflammatory bowel disease (IBD). There are conflicting results regarding …