A Gly15Arg mutation in the interleukin-10 gene reduces secretion of interleukin-10 in
Crohnʼs disease Page 51 CHAPTER 3 A Gly15Arg mutation in the interleukin-10 gene …

Genetic predisposition has been suggested to play an important role in the pathogenesis of
inflammatory bowel diseases (IBDs). Linkage studies have identified a Crohn's disease …

Interleukin‐18 (IL‐18) is believed to be one of the most important cytokines in the
pathogenesis of inflammatory bowel disease (IBD). The aim of the study was to clarify the …

Background and aims: Inflammation may play a role in the pathogenesis of irritable bowel
syndrome in some individuals, such as in those who develop symptoms following a …

AIM: To study the inflammatory bowel disease-5 locus (IBD5) and interleukin-23 receptor
(IL23R) gene variants in UC patients and test for gene-gene interaction. METHODS: The …

Background—Interleukin 1 (IL-1) α and β are potent cytokines which play key roles in
inflammation. They are controlled by IL-1 receptor antagonist (IL-1ra). Aims—To investigate …

Background Although there is strong evidence implicating genetic predisposition in the
pathogenesis of the chronic inflammatory bowel diseases, the number and identity of …

Dear Editor: Crohn's disease (CD; OMIM 266600) is a multi-factorial, polygenic disease
characterized by differential production of a number of cytokines that potentially contribute to …

Although the importance of genetic susceptibility to inflammatory bowel disease (IBD) has
been established by epidemiological studies, the genes involved remain poorly understood …

Background The inflammatory bowel diseases (IBD), Crohn's disease (CD) and ulcerative
colitis (UC), result from the combined effects of susceptibility genes and environmental …