No evidence for involvement of IL-4R and CD11B from the IBD1 region and STAT6 in the IBD2 region in Crohn's disease

DJ de Jong, B Franke, AHJ Naber… - European journal of …, 2003 - nature.com
Linkage studies have identified the inflammatory bowel disease (IBD) 1 locus on
chromosome 16 and the IBD2 locus on chromosome 12 to be involved in Crohn's disease …

The polymorphism rs3024505 proximal to IL-10 is associated with risk of ulcerative colitis and Crohns disease in a Danish case-control study

V Andersen, A Ernst, J Christensen, M Østergaard… - BMC medical …, 2010 - Springer
Background Crohns disease (CD) and ulcerative colitis (UC) are characterized by a
dysregulated inflammatory response to normal constituents of the intestinal flora in the …

Cytokine (TNFα, LTα and IL-10) polymorphisms in inflammatory bowel diseases and normal controls: differential effects on production and allele frequencies

K Koss, J Satsangi, GC Fanning, KI Welsh… - Genes & Immunity, 2000 - nature.com
The influence of biallelic polymorphisms in the tumour necrosis factor-alpha (TNFα),
lymphotoxin-alpha (LTα) and interleukin-10 (IL-10) genes on stimulated TNFα and IL-10 …

Genetic polymorphisms present in IL10, IL23R, NOD2, and ATG16L1 associated with susceptibility to inflammatory bowel disease in Mexican population

S Quiroz-Cruz, B Posada-Reyes… - European Journal of …, 2020 - journals.lww.com
Objective: Ulcerative colitis and Crohn's disease are the two clinical forms of inflammatory
bowel disease (IBD). Diverse studies have shown the association of single nucleotide …

Lack of association between pro-inflammatory genotypes of the interleukin-1 (IL-1B-31 C/+ and IL-1RN* 2/* 2) and gastric cancer/duodenal ulcer in Korean population

SG Lee, B Kim, W Choi, I Lee, J Choi, K Song - Cytokine, 2003 - Elsevier
IL-1β is a pro-inflammatory cytokine with multiple biological effects and is a potent inhibitor
of gastric acid secretion, and IL-1RN has been shown to be associated with enhanced IL-1β …

Role of Tumor Necrosis Factor-Alpha (C-863A) Polymorphism in Pathogenesis of Inflammatory Bowel Disease in Northern India

DK Ahirwar, P Kesarwani, R Singh, UC Ghoshal… - Journal of …, 2012 - Springer
Abstract Objective Inflammatory bowel diseases (IBDs), namely ulcerative colitis (UC) and
Crohn's disease (CD), are characterized by chronic and idiopathic inflammatory conditions …

Interleukin-6 in irritable bowel syndrome: A systematic review and meta-analysis of IL-6 (-G174C) and circulating IL-6 levels

M Bashashati, M Moradi, I Sarosiek - Cytokine, 2017 - Elsevier
Background Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder
which presents with abdominal pain and alterations of the bowel habits. The …

Influence of interleukin-10 on the interleukin-1 receptor antagonist/interleukin-1β ratio in the colonic mucosa of ulcerative colitis

K Ishizuka, K Sugimura, T Homma, J Matsuzawa… - Digestion, 2001 - karger.com
A decrease in the ratio of IL-1ra/IL-1β produced regionally by the colonic mucosa of patients
with ulcerative colitis (UC) is believed to play a role in the pathogenesis of UC. To …

The− 295T-to-C promoter polymorphism of the IL-16 gene is associated with crohn's disease

J Glas, HP Török, H Unterhuber, M Radlmayr… - Clinical …, 2003 - Elsevier
Recently, a T-to-C polymorphism at position− 295 in the promoter region of the human
interleukin-16 (IL-16) gene was reported. The expression of IL-16 is increased in …

Proinflammatory cytokine gene polymorphisms in irritable bowel syndrome

E Barkhordari, N Rezaei, B Ansaripour, P Larki… - Journal of clinical …, 2010 - Springer
Introduction Irritable bowel syndrome (IBS) is a multifactorial functional gastrointestinal
disorder, characterized by recurrent abdominal pain and altered bowel habits …