Background Barbiturates have previously been demonstrated to reduce focal cerebral
ischemic brain damage. However, the dose of drug required to elicit maximal …

Conclusion: Ces données contredisent l hypothèse de longue date voulant que des doses
comparables, au plan électrophysiologique, de diverses classes de barbituriques …

Background Reductions in cerebral metabolic rate may increase the brain's tolerance of
ischemia. However, outcome studies suggest that reductions in cerebral metabolic rate …

Background It has been postulated that anesthetic agents that reduce cerebral metabolic
rate will protect the brain against ischemia when electroencephalographic (EEG) activity is …

Background Although reduction of cerebral metabolic rate is thought to contribute to
anesthetic neuroprotection, histologic evidence to support this concept has not been …

Barbiturates have been demonstrated to reduce the cerebral metabolic rate (CMR) in a dose-
dependent manner but investigations of a dose-response relationship for their …

Background Although propofol is known to have effects on cerebral physiology similar to the
barbiturates, a direct comparison of the relative effects of these drugs on outcome from …

Object. Mild-to-moderate hypothermia is increasingly used for neuroprotection in humans.
However, it is unknown whether administration of barbiturate medications in burst …

Early observations in patients under general anesthesia set the stage for the concept that
anesthetic agents could also serve to protect the brain from an ischemic or hypoxic insult [1] …

Protecting the brain from ischemia during neurosurgery is one of the most important
concerns for anesthesiologists. It is amazing that, to my knowledge, there is a paucity of …