Natural killer (NK) cells are critical for both innate and adaptive immunity,. The development
of NK cells requires interactions between their progenitors and the bone-marrow …

Abstract Analysis of cytokine and differentiation antigen expression in human natural killer
(NK) cells revealed that interleukin 13 (IL-13) and interferon γ (IFN-γ) are produced at …

Invariant natural killer T cells (i NKT cells) can produce copious amounts of interleukin 4 (IL-
4) early during infection. However, indirect evidence suggests they may produce this …

Natural killer (NK) cells arise from immature progenitors present in fetal tissues and adult
bone marrow, but the factors responsible for driving the proliferation and differentiation of …

Natural killer (NK) cells are a subset of lymphocytes crucial for innate immunity and
modification of adaptive immune responses. In contrast to commitment to the T cell or B cell …

THE mechanism underlying the differentiation of CD4+ T cells into functionally distinct
subsets (Thl and Th2) is incompletely understood1–3, and hitherto unidentified cytokines …

Natural-killer (NK)-cell dysfunction and IFN-γ deficiencies have been associated with
increased incidence of both malignancy and infection. The immunologic basis of NK-cell …

Natural killer (NK) cells are innate cytotoxic lymphocytes with adaptive immune features,
including antigen specificity, clonal expansion and memory. As such, NK cells share many …

NK cell development is far less understood compared with that of T and B cells despite the
critical importance of NK cells in innate immunity. Mice lacking the transcription factor IFN …

While the specificity and development of natural killer (NK) cells have been intensely
studied, little is known about homeostasis of the mature NK population. Here we show that …