Requirement for IRF-1 in the microenvironment supporting development of natural killer cells
K Ogasawara, S Hida, N Azimi, Y Tagaya, T Sato… - Nature, 1998 - nature.com
Natural killer (NK) cells are critical for both innate and adaptive immunity,. The development
of NK cells requires interactions between their progenitors and the bone-marrow …
of NK cells requires interactions between their progenitors and the bone-marrow …
Final steps of natural killer cell maturation: a model for type 1–type 2 differentiation?
MJ Loza, B Perussia - Nature immunology, 2001 - nature.com
Abstract Analysis of cytokine and differentiation antigen expression in human natural killer
(NK) cells revealed that interleukin 13 (IL-13) and interferon γ (IFN-γ) are produced at …
(NK) cells revealed that interleukin 13 (IL-13) and interferon γ (IFN-γ) are produced at …
Steady-state production of IL-4 modulates immunity in mouse strains and is determined by lineage diversity of iNKT cells
Invariant natural killer T cells (i NKT cells) can produce copious amounts of interleukin 4 (IL-
4) early during infection. However, indirect evidence suggests they may produce this …
4) early during infection. However, indirect evidence suggests they may produce this …
Cytokine requirements for the growth and development of mouse NK cells in vitro
JA Toomey, F Gays, D Foster… - Journal of Leucocyte …, 2003 - academic.oup.com
Natural killer (NK) cells arise from immature progenitors present in fetal tissues and adult
bone marrow, but the factors responsible for driving the proliferation and differentiation of …
bone marrow, but the factors responsible for driving the proliferation and differentiation of …
The basic leucine zipper transcription factor E4BP4 is essential for natural killer cell development
DM Gascoyne, E Long, H Veiga-Fernandes… - Nature …, 2009 - nature.com
Natural killer (NK) cells are a subset of lymphocytes crucial for innate immunity and
modification of adaptive immune responses. In contrast to commitment to the T cell or B cell …
modification of adaptive immune responses. In contrast to commitment to the T cell or B cell …
Cloning of a new cytokine that induces IFN-γ production by T cells
H Okamura, H Tsutsui, T Komatsu, M Yutsudo… - Nature, 1995 - nature.com
THE mechanism underlying the differentiation of CD4+ T cells into functionally distinct
subsets (Thl and Th2) is incompletely understood1–3, and hitherto unidentified cytokines …
subsets (Thl and Th2) is incompletely understood1–3, and hitherto unidentified cytokines …
Tumor growth impedes natural-killer-cell maturation in the bone marrow
Natural-killer (NK)-cell dysfunction and IFN-γ deficiencies have been associated with
increased incidence of both malignancy and infection. The immunologic basis of NK-cell …
increased incidence of both malignancy and infection. The immunologic basis of NK-cell …
Control of nutrient uptake by IRF4 orchestrates innate immune memory
Natural killer (NK) cells are innate cytotoxic lymphocytes with adaptive immune features,
including antigen specificity, clonal expansion and memory. As such, NK cells share many …
including antigen specificity, clonal expansion and memory. As such, NK cells share many …
IFN regulatory factor-2 deficiency revealed a novel checkpoint critical for the generation of peripheral NK cells
NK cell development is far less understood compared with that of T and B cells despite the
critical importance of NK cells in innate immunity. Mice lacking the transcription factor IFN …
critical importance of NK cells in innate immunity. Mice lacking the transcription factor IFN …
[HTML][HTML] In vivo survival and homeostatic proliferation of natural killer cells
While the specificity and development of natural killer (NK) cells have been intensely
studied, little is known about homeostasis of the mature NK population. Here we show that …
studied, little is known about homeostasis of the mature NK population. Here we show that …