Endogenous β cell regeneration could alleviate diabetes, but proliferative stimuli within the
islet microenvironment are incompletely understood. We previously found that β cell …

Pancreatic islet endocrine cell and endothelial cell (EC) interactions mediated by vascular
endothelial growth factor-A (VEGF-A) signaling are important for islet differentiation and the …

Type 2 diabetes (T2D) results from insulin resistance and inadequate insulin secretion.
Insulin resistance initially causes compensatory islet hyperplasia that progresses to islet …

Immune modulation of pancreatic inflammation induces recovery from type 1 diabetes (T1D),
but remission was not durable, perhaps because of an inability to sustain the formation and …

The intra-islet microvasculature is a critical interface between the blood and islet endocrine
cells governing a number of cellular and pathophysiological processes associated with the …

The β-cell regeneration field has shown a strong knowledge boost in the last 10 years.
Pluripotent stem cell differentiation and direct reprogramming from other adult cell types are …

This review describes formation of the islet basement membrane and the function of
extracellular matrix (ECM) components in β-cell proliferation and survival. Implications for …

β-Cells respond to peripheral insulin resistance by first increasing circulating insulin during
diabetes. Islet remodeling supports this compensation, but its drivers remain poorly …

Within the pancreatic islet, the β-cell represents the ultimate biosensor. Its central function is
to accurately sense glucose levels in the blood and consequently release appropriate …

Background A physiological hallmark of patients with type 2 diabetes mellitus (T2DM) is β
cell dysfunction. Despite adequate treatment, it is an irreversible process that follows …