In recent years, the potential of stem cells (SCs) to differentiate into various types of cells,
including β-cells, has led to a significant boost in development. The efficiency of this …

Loss of insulin-producing β-cells is a central feature of diabetes. While a variety of potential
replacement therapies are being explored, expansion of endogenous insulin-producing …

Dedifferentiation has been implicated in β cell dysfunction and loss in rodent diabetes.
However, the pathophysiological significance in humans remains unclear. To elucidate this …

We have exploited islet-associated macrophages (IAMs) as a model of resident macrophage
function, focusing on more physiological conditions than the commonly used extremes of M1 …

Diabetes is characterized by high blood glucose level due to either autoimmune destruction
of islet β-cells or insufficient insulin secretion or glucose non-responsive production of …

Aims/hypothesis The proximity of endothelial cells and beta cells in islets by necessity
means that they are exposed to each other's products. Whereas islet endothelial cells …

The protection and interrogation of pancreatic β-cell health and function ex vivo is a
fundamental aspect of diabetes research, including mechanistic studies, evaluation of β-cell …

As a therapy for type I diabetes, islet transplantation provides clear benefits in terms of
increased insulinindependence and a reduced risk of hypoglycemia. However, a critical …

Pancreatic islets consist of 60-80% beta cells, which secrete insulin, a hormone of profound
importance in the regulation of carbohydrate, fat and protein metabolism. Beta cell death …

Loss of functional beta-cells is fundamental in both type 1 and type 2 diabetes. In situ beta-
cell regeneration therefore has garnered great interest as an approach to diabetes therapy …