It is generally accepted that vascularization and oxygenation of pancreatic islets are
essential for the maintenance of an optimal β-cell mass and function and that signaling by …

Although stem cell populations mediate regeneration of rapid turnover tissues, such as skin,
blood, and gut, a stem cell reservoir has not been identified for some slower turnover …

Developmental stage-specific differentiation of stem or progenitor cells into safe and
functional cells is of fundamental importance in regenerative medicine, including β-cell …

In-vitro expansion of insulin-producing cells from adult human pancreatic islets could
provide an abundant cell source for diabetes therapy. However, proliferation of β-cell …

Blood vessel networks provide nutrients and gaseous exchange that are essential for
functions. Pancreatic islet capillaries deliver oxygen to endocrine cells while transporting …

Islet transplantation is an established clinical procedure for select patients with type 1
diabetes and severe hypoglycemia to stabilize glycemic control. Post-transplant, substantial …

In experimental studies, pancreatic islet microvasculature is essential for islet endocrine
function and mass, and islet vascular morphology is altered in diabetic subjects. Even so …

As recent studies suggest that newly formed pancreatic β-cells are a result of self-duplication
rather than stem cell differentiation, in vitro expansion of β-cells presents a potential …

The mechanisms that regulate pancreatic β cell mass are poorly understood. While
autoimmune and pharmacological destruction of insulin-producing β cells is often …

Owing to strong interactions between pancreatic islets and the surrounding capillary
network, we hypothesized that high glucose concentrations might affect key angiogenesis …